茶叶科学2019，Vol.39Issue(6)：641-651,11.
茯砖茶提取物对葡聚糖硫酸钠诱导小鼠炎症性肠病的保护作用研究
Protective Effects of Fu Brick Tea Extracts on Inflammatory Bowel Disease Induced by Dextran Sulfate Sodium in Mice
胡安恺 1姚立筠 2赵悦伶 2刘畅 1王岳飞 2徐平2
作者信息
- 1. 东北农业大学食品学院乳品工程系,黑龙江 哈尔滨 150030
- 2. 浙江大学茶叶研究所,浙江 杭州 310058
- 折叠
摘要
Abstract
Fu brick tea is a special dark tea in China. In the present work, three extracts, including Fu brick tea water extract (FWE), Fu brick tea ethanol soluble fraction (FES) and Fu brick tea ethanol precipitation fraction(FEP), were prepared and used to further explore their protective effects on inflammatory bowel disease in mice. Researches show that all the Fu brick tea extracts could alleviate the intestinal structure damage of IBD mice. Moreover, the extracts increased the activities of SOD, CAT and the levels of GSH and reduced the levels of IL-6, IL-1β, TNF-α in serum and colon tissue supernatant of mice. Furthermore, the protein level of NF-κB p65 in the colon tissues in the FWE group was decreased compared to the model group. The protein level of IκBα was increased in the FWE group and FES group. Levels of Nrf2 and HO-1 were also increased in the FWE and FES groups. In conclusion, Fu brick tea extracts had a protective effect on IBD mice induced by DSS.关键词
茯砖茶/炎症性肠病(IBD)/炎症/氧化应激Key words
Fu brick tea/inflammatory bowel disease/inflammation/oxidative stress分类
农业科技引用本文复制引用
胡安恺,姚立筠,赵悦伶,刘畅,王岳飞,徐平..茯砖茶提取物对葡聚糖硫酸钠诱导小鼠炎症性肠病的保护作用研究[J].茶叶科学,2019,39(6):641-651,11.
