食品科学2019，Vol.40Issue(24)：128-135,8.DOI:10.7506/spkx1002-6630-20180728-346
汉族和藏族婴儿肠道微生物群落结构和多样性分析
Structural Segregation of the Gut Microbiome between Chinese Han and Tibetan Infants
摘要
Abstract
Ethnicity is considered as one of the major driving forces to shape the human gut microbiota,but how the gut microbiota evolves in population with disparate ethnic backgrounds since infants are born remains still unclear.Thus,this study aimed to understand the impact of ethnicity on infants.We investigated the fecal microbiota of healthy infants (3-6 months old,with breast feeding) from the Chinese Han and Tibetan ethnic groups (n =10 for each group).By using high-throughput 16S rRNA gene sequencing analyses,we found some differences in fecal microbiota composition between the two groups.At the phylum level,the Han infants harbored higher relative abundance of Actinobacteria,whereas Firmicutes was more predominant in the Tibetans.A significant difference at the phylum level existed in Firmicutes (P ＜ 0.05) between the two groups.Bifidobacterium and Escherichia-Shigella were the first and second major genera in both groups,respectively.There was a clear separation between the groups by principal coordinates analysis (PCoA) based on unweighted and weighted UniFrac distance.Moreover,partial least squares-discriminant analysis (PLS-DA) showed that the infant gut microbiome was segregated according to ethnicity.Taken together,our findings suggest that the gut microbiota could be differentiated between infants from distinct ethnic origins,and this expanded our knowledge of the co-evolution of human hosts and their symbiotic gut microbiota.关键词
婴儿/肠道微生物/民族/共同进化Key words
infant/gut microbiota/ethnicity/co-evolution分类
生物科学引用本文复制引用
张秋雪,尚佳萃,朱德全,朱宗涛,万峰,贾芳芳,孙思睿,孟祥晨..汉族和藏族婴儿肠道微生物群落结构和多样性分析[J].食品科学,2019,40(24):128-135,8.基金项目
“十三五”国家重点研发计划重点专项(2017YFD0400304) （2017YFD0400304）
