食品工业科技2021，Vol.42Issue(14)：320-327,8.DOI:10.13386/j.issn1002-0306.2020090140
葛仙米对高脂血症小鼠氧化应激的保护作用
Protective Effect of Nostoc sphaeroids Kütz on Oxidative Stress in Hyperlipidemic Mice
刘银路 1杨丽涛 1毕萃萃 1魏芬芬 1张波1
作者信息
- 1. 北京联合大学功能食品科学技术研究院, 生物活性物质与功能食品北京市重点实验室,北京 100191
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摘要
Abstract
Most health problems associated with aging, such as wrinkles, heart disease and Alzheimer's disease were caused by excessive oxidative stress in the body. Hyperlipidemia caused by high-fat diet(HFD) would lead to lipid metabolism disorder, oxidative stress and so on. The purpose of this study was to investigate the protective effect of Nostoc sphaeroids Kütz(NSK) on diet-induced hyperlipidemia in mice. In the experiment, six-week-old C57BL/6j male mice were fed with high-fat diet(HFD) for 4 weeks, and then fed with high-fat diet supplemented with different doses of NSK for 6 weeks. Results showed that: High-fat diet could lead to hyperlipidemia and obvious dyslipidemia in mice. The addition of NSK to high-fat diet decreased serum triglyceride(TG), serum total cholesterol(TC), low density lipid cholesterol(LDL-C), while high density lipid cholesterol(HDL-C) increased significantly(P<0.05). It could also significantly reduce the liver index and the enzyme activities of alanine transaminase(ALT) and aspartate transaminase(AST). Through the results of this experiment, it was found that the level of malondialdehyde (MDA) in the liver tissue of 2.5％ and 7.5％ NSK group decreased, while total antioxidant capacity(T-AOC), hepatic superoxide dismutase(SOD) and glutathione(GSH) increased, and the difference was statistically significant(P<0.05). Furthermore, the expression of LDLR,CYP7a1 and LXR-α in liver tissue of mice supplemented with NSK in HFD significantly increased(P<0.05). In conclusion, NSK hadlipid-lowering effect on HFD-fed mice and it might be related to increase the antioxidant activity and gene expression of LDLR and CYP7a1.关键词
葛仙米/高脂血症/小鼠/氧化应激Key words
Nostoc sphaeroids Kütz/hyperlipidemia/mice/oxidative stress分类
轻工纺织引用本文复制引用
刘银路,杨丽涛,毕萃萃,魏芬芬,张波..葛仙米对高脂血症小鼠氧化应激的保护作用[J].食品工业科技,2021,42(14):320-327,8.
