食品科学2021，Vol.42Issue(12)：8-16,9.DOI:10.7506/spkx1002-6630-20200414-185
魔芋葡甘聚糖和壳聚糖-富里酸纳米颗粒组成的pH值响应性水凝胶的制备
Fabrication of pH-Responsive Hydrogels Composed of Chitosan-Fulvic Acid Microparticles and Konjac Glucomannan
摘要
Abstract
A series of konjac glucomannan (KGM) hydrogels were prepared using chitosan-fulvic acid microparticles(CFMPs) as the reinforcing agents.CFMPs possessed high surface density and oxygen-containing functional groups,which could induce hydrogen-bonding interaction between KGM and CFMPs to form a more dense network structure.The effects of CFMPs on the network structure and releaseing behavior of KGM hydrogels were evaluated.The rheological results revealed that the regular change in the steady shear viscosity and dynamic viscoelasticity of all hydrogel-forming solutions was attributed to the reinforced network structure with strong interaction.Fourier transform infrared spectral analysis indicated that the carboxyl groups (-COOH) in CFMPs successfully formed hydrogen bonds with the hydroxyl groups (-OH) in the KGM polymer chains.Scanning electron microscopic images revealed that the structure of hydrogels was dense with interconnected pores.In addition,the in vitro drug-releasing behavior of KGM/CFMP hydrogels in artificial intestinal and gastric fluids was investigated.KGM/CFMP composite hydrogels possessed excellent pH-responsive property due to the protonated amine groups (-NH3+).Therefore,KGM/CFMP composite hydrogels have a huge potential as a pH-responsive drug delivery system.关键词
魔芋葡甘聚糖/壳聚糖-富里酸纳米颗粒/水凝胶/pH值响应性释药Key words
konjac glucomannan/chitosan-fulvic microparticles/hydrogel/pH-controlled release分类
化学化工引用本文复制引用
陈晓涵,庞杰..魔芋葡甘聚糖和壳聚糖-富里酸纳米颗粒组成的pH值响应性水凝胶的制备[J].食品科学,2021,42(12):8-16,9.基金项目
国家自然科学基金面上项目(31772045) （31772045）
