CT理论与应用研究2023，Vol.32Issue(6)：746-752,7.DOI:10.15953/j.ctta.2022.253
CT增强定量参数预测肾透明细胞癌WHO/ISUP分级
Prediction of WHO/ISUP Grading of Renal Clear Cell Carcinoma by Quantitative Parameters of CT Enhancement Scanning
张晓金 1翟建 2张虎 1谢闵 3吴树剑 2过永1
作者信息
- 1. 芜湖市第二人民医院医学影像科,安徽 芜湖 241000
- 2. 皖南医学院弋矶山医院医学影像中心,安徽 芜湖 241000
- 3. 芜湖市第二人民医院医学病理科,安徽 芜湖 241000
- 折叠
摘要
Abstract
Objective:To investigate the potential of CT-enhanced quantitative parameters for preoperative prediction of WHO/ISUP grading for renal clear cell carcinoma(ccRCC).Methods:The study involved collecting clinical and CT-enhanced data of 98 patients with ccRCC,who were then classified into low level group(76 cases)and high level group(22 cases)based on the WHO/ISUP classification.Differences in CT-enhanced quantitative parameters between the two groups were compared,and the diagnostic efficacy of each parameter for predicting ccRCC WHO/ISUP grading was evaluated.External verification was conducted to identify CT-enhanced quantitative parameters with the best generalization ability.Results:There were significant differences in the CT value,net increment,and enhancement rate in both cortical and substantive phases between the two groups.The AUC values were 0.834,0.871,0.900,0.707,0.678,and 0.762,respectively.The cut-off values were 123.5 HU,71 HU,0.73,87.5 HU,54 HU,0.67,respectively.The diagnostic efficacy of cortical enhancement rate was the highest with an AUC of 0.900,a sensitivity of 0.842,and a specificity of 0.864.The external validation results revealed that the diagnostic efficacy of cortical phase enhancement rate(AUC = 0.867)was better than that of cortical phase CT(AUC = 0.735)and cortical phase net increment(AUC = 0.709).The Z values were 2.134 and 2.417,respectively.Conclusion:The quantitative parameters of CT enhancement can be used to predict ccRCC WHO/ISUP grading.Cortical phase enhancement rate is the parameter with the highest diagnostic efficiency and the best generalization ability.关键词
体层摄影术/X线计算机/透明细胞肾癌/病理分级Key words
tomography/X-ray computer/clear cell renal carcinoma/pathological grading分类
医药卫生引用本文复制引用
张晓金,翟建,张虎,谢闵,吴树剑,过永..CT增强定量参数预测肾透明细胞癌WHO/ISUP分级[J].CT理论与应用研究,2023,32(6):746-752,7.
