食品工业科技2024，Vol.45Issue(1)：318-324,7.DOI:10.13386/j.issn1002-0306.2023030168
浒苔多酚对2型糖尿病小鼠降血糖功效研究
Effect of Polyphenols from Enteromorpha proliferaon Reducing Blood Glucose in Type 2 Diabetic Mice
摘要
Abstract
Objective:The aim of this work was to explore the hypoglycemic effect of Enteromorpha prolifera polyphenols(EPP)on type 2 diabetic mice,and to provide theoretical basis for the development of EPP products.Methods:EPP crude was extracted from Enteromorpha prolifera by ethanol solution extraction,and purified by silica gel column chromatography.The model of type 2 diabetes in mice was established by alloxan.The experimental mice were divided into blank control group,model control group,EPP low dose group(EPP-L),EPP midium dose group(EPP-M),EPP high dose group(EPP-H),and positive control group.The basic indicators of mice,as well as lipid metabolism and serum antioxidant indicators,were measured by continuous gastric perfusion for 4 weeks.Results:At the 4th week of the experiment,the averaged weight of mice in EPP-H group reached 32.16±1.97 g,which was not significantly different from that of the positive control group(P>0.05).The fasting blood glucose concentration of EPP-H group was 11.78±1.62 mmol/L,and there was no significant difference between EPP-H group and the positive control group(P>0.05).EPP-H clearly had significantly improved both the glucose tolerance(P<0.05)and the abnormal glucose tolerance of mice.The concentrations of superoxide dismutase,catalase,glutathione peroxidase,high-density lipoprotein cholesterol,and serum insulin levels in EPP-H mice were 157.36±6.71 U/mg,168.07±1.77 U/mg,378.14±9.74 U/mg,1.31±0.04 mmol/L,and 19.03±2.01 mU/L,respectively,compared with the model control group,it was significantly increased(P<0.01),and the contents of malondialdehyde,triglyceride,total cholesterol and low-density lipoprotein cholesterol were significantly decreased(P<0.05).Conclusion:Polyphenols from Enteromorpha prolifera can effectively improve the basal metabolism of type 2 diabetic mice and repair the peroxide damage of diabetic mice,and may play a role in lowering blood sugar.关键词
浒苔/多酚/降血糖/功效Key words
Enteromorpha prolifera/polyphenols/hypoglycemic/efficacy分类
轻工纺织引用本文复制引用
邱小明,郭欣,黄聪亮..浒苔多酚对2型糖尿病小鼠降血糖功效研究[J].食品工业科技,2024,45(1):318-324,7.基金项目
漳州市食品产业技术研究院开放课题(ZSY2022105) （ZSY2022105）
漳州市自然科学基金项目(ZZ2020J43) （ZZ2020J43）
福建省科技厅星火计划项目(2020S0037). （2020S0037）
