食品与发酵工业2023，Vol.49Issue(24)：21-28,8.DOI:10.13995/j.cnki.11-1802/ts.035073
两歧双歧杆菌调控肠道生物屏障改善抗生素引起的肠动力及结构损伤
Bifidobacterium bifidum modulates the intestinal biological barrier to improve antibiotic-induced intestinal dynamics and structural impairment
摘要
Abstract
Oral antibiotic administration alters the composition of the intestinal microbiota.In this study,we examined the effects of antibiotics of different antimicrobial profiles on intestinal dynamics,intestinal structure,and intestinal nerves in mice.Then we evaluated the repair potential of different sources of bifidobacteria on intestinal structure,function,and intestinal nerve damage caused by broad-spectrum antibiotics in mice.Firstly,antibiotics inhibiting G+bacteria(ampicillin),antibiotics inhibiting G-bacteria(gentamicin),and broad-spectrum antibiotics were applied to treat mice for 21 days,and small intestinal length,colonic length,cecum weight,small in-testinal propulsion rate,whole intestinal transit time,and colonic enteric nerve indices were examined.The results showed that gentami-cin-treated group had significantly greater effects on intestinal structure,function,and enteric neurological effects were significantly greater than those of the remaining two groups.Secondly,three strains of Bifidobacterium bifidum were applied to the broad-spectrum antibiotic-treated group for 7 days,and the effects of them on intestinal dynamics,intestinal structure and the nervous system of mice were exam-ined,and the results showed that B.bifidum 45M3 repaired the damage to intestinal structure and function caused by broad-spectrum anti-biotics by modulating the intestinal biological barrier.In conclusion,antibiotics with different antimicrobial profiles have different effects on intestinal structure,intestinal dynamics and intestinal nerves in mice,among which antibiotics that inhibit G-bacteria have the grea-test effect,while B.bifidum 45M3 has the potential to repair the structural and functional damage to the intestine caused by broad-spec-trum antibiotics.This study provides a theoretical basis for probiotic supplementation after taking antibiotics and a new idea for developing new functional foods to enhance citizen's health.关键词
两歧双歧杆菌/抗生素/肠道结构/生物屏障Key words
Bifidobacterium bifidum/antibiotics/intestinal structure/biological barrier引用本文复制引用
余强庆,唐楠,王嘉良,梅春霞,王琳琳,王刚,张灏,赵建新..两歧双歧杆菌调控肠道生物屏障改善抗生素引起的肠动力及结构损伤[J].食品与发酵工业,2023,49(24):21-28,8.基金项目
国家自然科学基金面上项目(32172213) （32172213）
