磷酸化修饰介导的病原微生物致病机制研究OACSTPCD

Pathogenic microorganisms release a series of effector proteins to their hosts through a special secretion system,which can interfere with the host's innate immunity-related signaling pathways,causing the occurrence of disease and even leading to the host's deaths,which is an im-portant means for their virulence.It is widely realized that post-translational modifications mediated by effectors play a crucial role in the process of pathogenic microbial infections.Phosphorylation is one of the most common post-translational modifications,which is achieved by kinases,and many effector proteins in numerous pathogenic microorganisms have been found to have serine/threonine kinase activity so far.With the help of these efficient effector proteins with kinase activity,patho-genic microorganisms can phosphorylate host-specific target proteins,thereby interfering with their normal signal transduction in host cells,leading to the inhibition of host immune defense responses,causing serious harm to the host,and promoting the reproduction and expansion of pathogenic mi-croorganisms in the host.This study provides an overview of recently identified effector proteins with kinase activity in pathogenic microorganisms,offering a reference for a better understanding of phos-phorylation modification-mediated pathogenic microbial infection and guiding drug design for the treatment of pathogenic microorganism infections.