食品工业科技2024，Vol.45Issue(2)：342-348,7.DOI:10.13386/j.issn1002-0306.2023030237
牡丹雄蕊对慢性非细菌性前列腺炎大鼠模型的影响
Effect of Paeonia suffruticosa Andr.Stamens on Rat Model of Chronic Abacterial Prostatitis
摘要
Abstract
In order to investigate the pharmacological effect of Paeonia suffruticosa Andr.stamens on chronic non-bacterial prostatitis(CNBP)in rats,the rats with chronic abacterial prostatitis induced by castration combined subcutaneous injection of hormone(estradiol benzoate 0.25 mg·kg-1)were used as models.Forty rats with CNBP were randomly divided into five groups(8 per group):Model group(normal saline),positive group(celecoxib 250 mg·kg-1),various doses of lyophilized powder of Paeonia suffruticosa Andr.stamens groups(100,200,400 mg·kg-1).Another group of normal mice treated with normal saline as normal group.The therapeutic effect of Paeonia suffruticosa Andr.stamens on CNBP was evaluated by lecithin body density,prostatic index,cytokines in prostate tissue and the expression levels of TXB2 and 6-K-PGF1α in blood.The results showed that the inflammation of prostate tissue in rats was significantly improved.Compared with model group,the number of white blood cells,prostate weight,prostate index,TXB2 and the content of PGE2 in prostate tissue of rats were significantly decreased in each dosage group of Paeonia suffruticosa Andr.stamens(P<0.01,P<0.05).The cont-ents of ICAM-1,INF-γ,TNF-α,MCP-1 and IL-8 in high-dose group of Paeonia suffruticosa Andr.stamens were signi-ficantly decreased(P<0.01,P<0.05),and in low-dose group were also decreased,but there was no significant difference(P>0.05).The contents of 6-keto-PGF1α and NO in high dose of Paeonia suffruticosa Andr.stamens were significantly increased(P<0.01,P<0.05),and in low dose group were also increased,but there was no significant difference(P>0.05).This study showed that Paeonia suffruticosa Andr.stamens had therapeutic effect on chronic abacterial prostatitis,which would provide a theoretical basis for further development and application of the Paeonia suffruticosa Andr.stamens.关键词
牡丹雄蕊/慢性非细菌性前列腺炎/苯甲酸雌二醇/炎症因子Key words
Paeonia suffruticosa Andr.stamens/chronic nonbacterial prostatitis(CNBP)/estradiol benzoate/inflammatory factor分类
轻工纺织引用本文复制引用
程丹丹,高德民,王岱杰,梁栋,庞志勇,徐亚振,王惠敏,袁文鹏..牡丹雄蕊对慢性非细菌性前列腺炎大鼠模型的影响[J].食品工业科技,2024,45(2):342-348,7.基金项目
山东省重点研发计划-药食同源特色产品创新研发与应用示范(2021SFGC1205) （2021SFGC1205）
科教产融合试点工程重大创新专项-鲁西南特色植物资源全链条关键技术研发及应用示范(2022JBZ02-06) （2022JBZ02-06）
甘肃临夏州国家级牡丹基因库建设及推广应用(YDZX2021103). （YDZX2021103）
