现代妇产科进展2024，Vol.33Issue(1)：37-40,46,5.DOI:10.13283/j.cnki.xdfckjz.2024.01.007
HRT-FET周期中雌激素水平与妊娠期高血压发生的关系
Association between estrogen level and incidence of HDP after HRT-FET
摘要
Abstract
Objective:To explore the effect of serum estrogen level(E2)prior to pro-gesterone administration on incidence of hypertensive disorders of pregnancy(HDP)in single-tons born after frozen embryo transfer(FET)using hormone replacement therapy(HRT)cy-cles.Method:This retrospective study included 3506 singletons after HRT-FET from May 2017 to May 2022.Patients were divided into 3 groups according to the serum E2 levels before endo-metrial transformation:Group 1(E2≤137pg/mL),Group 2(137pg/mL<E2≤240pg/mL),Group3(E2>240pg/mL).The incidence of obstetric complications and perinatal outcomes were compared among groups.Results:The incidence of HDP was statistically increased in Group 3 compared with Group 1(aOR=0.653,95%CI 0.463～0.920,P=0.015)and Group 2(aOR= 0.750,95%CI 0.566～0.994,P=0.045).The incidences of gestational diabetes mellitus,pla-centa previa,postpartum hemorrhage,preterm labor,post-term labor,large for gestational age(LGA),small for gestational age(SGA)were comparable among groups.Conclusion:High E2 level was an independent risk factor for HDP in patients with singletons born after HRT-FET.关键词
激素替代疗法/冻胚移植/雌二醇/妊娠期高血压疾病Key words
Hormone replacement therapy/Frozen embryo transfer/Serum estrogen level/Hypertensive disorders of pregnancy分类
医药卫生引用本文复制引用
鲁娟娟,邵雨菡,张倩,倪天翔,王泽,李敬,颜军昊..HRT-FET周期中雌激素水平与妊娠期高血压发生的关系[J].现代妇产科进展,2024,33(1):37-40,46,5.基金项目
国家重点研发计划(No:2021YFC2700604) （No:2021YFC2700604）
山东省重点研发计划(No:2021LCZX02) （No:2021LCZX02）
