海南医学院学报2024，Vol.30Issue(1)：67-74,8.DOI:10.13210/j.cnki.jhmu.20230506.002
铁死亡的发生机制及其在乳腺癌治疗中的作用
Molecular mechanisms of ferroptosis and its role in the treatment of breast cancer
摘要
Abstract
Breast cancer is a critical threat to women around the globe.Current radio-and chemotherapy regimens can in-duce multiple drug-resistant effects,e.g.,anti-apoptosis,anti-pyroptosis,and anti-necroptosis,causing a poor clinical response to therapy.Ferroptosis is a newly programmed cell death characterized by iron overload,the massive production of reactive oxygen species,and membrane lipid peroxidation.The occurrence of ferroptosis results from an imbalance between peroxidation mecha-nisms(execution systems)and anti-oxidation mechanisms(defense systems),including the iron metabolism pathway,amino acid metabolism pathway,and lipid metabolism pathway.Recently,the vital role of ferroptosis in various diseases,including cancer,hypertension,diabetes,and Alzheimer's,has been identified.Specifically,triggering ferroptosis in breast cancer cells can inhibit their proliferation and invasion,and improve the chemoradiotherapy sensitivity,which makes it a potential strategy for breast can-cer therapy.This review summarizes the definition and features of ferroptosis,as well as its role in the treatment of breast cancer,aimed at providing a theoretical basis for future drug development.关键词
乳腺癌/铁死亡/谷胱甘肽/谷胱甘肽过氧化物酶4/活性氧Key words
Breast cancer/Ferroptosis/Glutathione/Glutathione peroxidase 4/Reactive oxygen species分类
医药卫生引用本文复制引用
敬波,陈恒余,吴煌福..铁死亡的发生机制及其在乳腺癌治疗中的作用[J].海南医学院学报,2024,30(1):67-74,8.基金项目
This study was supported by the National Natural Science Foundation of China(82203813) 国家自然科学基金资助项目(82203813) （82203813）
