食品科学2023，Vol.44Issue(23)：282-292,11.DOI:10.7506/spkx1002-6630-20221229-273
益生菌缓解高尿酸血症作用机制研究进展
Progress in Understanding the Mechanism by Which Probiotics Alletivate Hyperuricemia
摘要
Abstract
Hyperuricemia(HUA)is a disease caused by excessive production and/or inadequate excretion of uric acid(UA)in the body,and persistent HUA can lead to gout.Asymptomatic HUA is closely related to other metabolic diseases,such as chronic kidney disease,diabetes and cardiovascular disease.Probiotic intervention is a potentially safe,cost-effective treatment to improve HUA.This paper mainly describes the mechanisms of action of probiotics in reducing the level of uric acid,including inhibiting xanthine oxidase activity,absorbing and degrading purines in the intestine,regulating intestinal flora homeostasis and restoring intestinal barrier function.In addition,probiotics can promote uric acid excretion and consequently reduced uric acid levels by promoting the expression of urate transport proteins and inhibiting the expression of urate reabsorbing proteins.Probiotics have great potential in alleviating HUA.This review hopes to provide a theoretical basis for subsequent research.关键词
高尿酸血症/痛风/益生菌/机制/研究进展Key words
hyperuricemia/gout/probiotics/mechanism/research progress分类
轻工业引用本文复制引用
黄佳豪,李先平,赵军英,乔为仓,刘璐,陈历俊..益生菌缓解高尿酸血症作用机制研究进展[J].食品科学,2023,44(23):282-292,11.基金项目
国家自然科学基金面上项目(32072191) （32072191）
中央引导地方科技发展专项资金项目(桂科ZY22096025) （桂科ZY22096025）
家畜产业技术体系北京市创新团队项目(BAIC05-2022) （BAIC05-2022）
