食品科学2023，Vol.44Issue(24)：34-40,7.DOI:10.7506/spkx1002-6630-20230404-032
负载鳙鱼肽的壳聚糖/三聚磷酸钠和壳聚糖/亚麻籽胶复合纳米颗粒的稳定性和生物相容性评价
Evaluation of Stability and Biocompatibility of Chitosan/Sodium Tripolyphosphate and Chitosan/Flaxseed Gum Composite Nanoparticles Loaded with Bighead Carp Peptides
摘要
Abstract
Chitosan nanoparticle is becoming an excellent carrier for the delivery of bioactive components due to the advantages of simple preparation,low cost and high biocompatibility.Previous studies have shown that chitosan/sodium tripolyphosphate(CS/TPP)and chitosan/flaxseed gum(CS/FG)nanoparticles loaded with bighead carp peptides(BCP)have the advantages of small particle size,high encapsulation rate and significant slow-release effect.This study explored the effects of ionic strength,pH,simulated digestion and storage time on the preparation of chitosan/sodium tripolyphosphate(CS/TPP-BCP)and chitosan/flaxseed gum(CS/FG-BCP)nanoparticles,and evaluated the extracellular lactate dehydrogenase content and antioxidant capacity in vivo of Caco-2 cells treated with the chitosan nanoparticles and their cellular uptake.The results showed that the two kinds of chitosan nanoparticles were stable under acidic conditions and sensitive to a solution with opposite charges.The stability of the nanoparticles loaded with bighead peptides was higher than that of free peptides and both nanoparticles showed higher biocompatibility and cell uptake.关键词
壳聚糖/纳米颗粒/稳定性/生物相容性Key words
chitosan/nanoparticle/stability/biocompatibility分类
轻工业引用本文复制引用
郑昌亮,郭晓嘉,吴文锦,杨玉平,陈梦婷,汪兰,曲映红,施文正,石柳,陈胜,乔宇,李新..负载鳙鱼肽的壳聚糖/三聚磷酸钠和壳聚糖/亚麻籽胶复合纳米颗粒的稳定性和生物相容性评价[J].食品科学,2023,44(24):34-40,7.基金项目
"十三五"国家重点研发计划重点专项(2019YFD0901805) （2019YFD0901805）
湖北省农机装备补短板核心技术应用攻关项目(HBSNYT202221) （HBSNYT202221）
