104例儿童中药注射剂不良反应分析OACSTPCD
Analysis of Adverse Drug Reactions Induced by Traditional Chinese Medicine Injections in 104 Children
目的:分析儿童中药注射剂不良反应(ADR)发生情况,为临床合理用药提供参考.方法:从国家药品ADR监测系统中收集2006-2021年中成药不良反应案例1 356例,筛选出中药注射剂在儿童中发生的ADR共104例.从患儿因素、药物因素及临床因素3个角度对ADR的特点及原因进行分析.结果:男65例(62.50％),女39例(37.50％);≤5岁59例(56.73％);复方制剂63例(60.58％),单一组分制剂41例(39.42％);用药后30 min内发生ADR 86例(82.69％).结论:儿童尚处于生长发育阶段,需要重视中药注射剂在儿童中的应用,谨慎用药,加强监测,以减少或避免ADR的发生.
Objective:To analyze the occurrence of adverse drug reactions(ADR)induced by traditional Chinese medicine injections in children,so as to provide reference for rational drug use in clinic.Methods:A total of 1,356 cases of ADR induced by Chinese patent medicines were collected from the National ADR Monitoring System from 2006 and 2021.Totally 104 cases of ADR induced by traditional Chinese medicine injections in the pediatric population were selected for analysis.The characteristics and causes of ADR were analyzed from three perspectives:patient factors,drug factors and clinical factors.Results:Of the 104 cases,65 cases(62.50％)were males and 39 cases(37.50％)were females.In the age group of ≤5 years,there were 59 cases(56.73％).Composite formulations accounted for 63 cases(60.58％),while single-component formulations accounted for 41 cases(39.42％).ADR occurred within 30 minutes after administration in 86 cases(82.69％).Conclusion:As children are still in the stage of growth and development,attention should be paid to the use of traditional Chinese medicine injections.Prudent drug use,enhanced monitoring,and measures to reduce or avoid ADR are recommended.
许剑;唐志华
绍兴市人民医院,浙江绍兴 312000
药学
儿童中成药中药注射剂不良反应
childrenChinese patent medicinestraditional Chinese medicine injectionsadverse drug reactions
《儿科药学杂志》 2024 (001)
21-23 / 3
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