食品工业科技2024，Vol.45Issue(3)：363-371,9.DOI:10.13386/j.issn1002-0306.2023030093
人乳低聚糖与肠道菌群互作及其调节婴儿免疫功能的研究进展
Research Progress on HMOs Interacting with Intestinal Flora to Regulate Infant Immune Function
摘要
Abstract
Human milk oligosaccharides(HMOs)are very important components in human milk,and more than 200 different HMOs have been identified so far.HMOs act as prebiotics by the metabolism of gut microbiota to produce short-chain fatty acids,which have a beneficial effect on infant health.This is one of the main differences between breast milk and formula milk powder.Studies have shown that different species of gut microbiota use different mechanisms to recognize and digest HMOs with different structures,maintaining the balance of the gut microbiota.HMOs also have a variety of functions such as relieving allergic symptoms and preventing necrotizing enterocolitis.In this paper,the type,structure and content of HMOs,interaction between HMOs and infant gut microbiota,and their immune regulatory functions are reviewed.HMOs can promote colonization and growth of gut microbiota in infants,and directly or indirectly regulate the infant immune function.This paper provides theoretical support for the application of HMOs in infant foods,and contributes new ideas to the future research and development direction.关键词
母乳低聚糖/岩藻糖基化/肠道菌群/免疫/抵抗病原体粘附Key words
human milk oligosaccharides/fucosylation/intestinal flora/immune properties/resistance to pathogen adhesion分类
轻工业引用本文复制引用
徐颢轩,刘婧雯,尚佳萃,孟祥晨..人乳低聚糖与肠道菌群互作及其调节婴儿免疫功能的研究进展[J].食品工业科技,2024,45(3):363-371,9.基金项目
国家自然科学基金项目(32272291). （32272291）
