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牡蛎提取物对秀丽隐杆线虫的抗衰老作用研究

魏润霞 卢虹玉 秦小明 王丽瑶

食品与发酵工业2024,Vol.50Issue(1):52-58,7.
食品与发酵工业2024,Vol.50Issue(1):52-58,7.DOI:10.13995/j.cnki.11-1802/ts.037222

牡蛎提取物对秀丽隐杆线虫的抗衰老作用研究

Anti-aging effects of oyster extracts on Caenorhabditis elegans

魏润霞 1卢虹玉 2秦小明 2王丽瑶1

作者信息

  • 1. 广东海洋大学食品科技学院,广东省水产品加工与安全重点实验室,广东省海洋生物制品工程实验室,广东省海洋食品工程技术研究中心,水产品深加工广东普通高等学校重点实验室,广东湛江,524008
  • 2. 广东海洋大学食品科技学院,广东省水产品加工与安全重点实验室,广东省海洋生物制品工程实验室,广东省海洋食品工程技术研究中心,水产品深加工广东普通高等学校重点实验室,广东湛江,524008||大连工业大学,海洋食品精深加工关键技术省部共建协同创新中心,辽宁大连,116034
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摘要

Abstract

To compare the anti-aging effects of two oyster enzymatic extracts,including enzymolysis extract of oyster(EPO),oyster peptide(OP),and oyster water extract(WPO),the basic components of the three oyster extracts were determined,and Caenorhabditis elegans was used as an animal model to study the effects of oyster extracts on lifespan,reproduction,lipofuscin accumulation,athletic ability,acute oxidative stress injury,and redox level in the body.Results showed that the basic components of EPO,OP,and WPO were different,but the main components were all proteins.Among them,OP had the highest total protein content with(66.59±0.57)g/100 g dry basis.Compared with control,the low,medium,and high concentrations(50,200,800 μg/mL)of EPO,OP,and WPO prolonged C.elegans lifespan,but the effect was not significant at low concentrations.Between three oyster extracts,only OP significantly increased the egg production of C.elegans in a concentration-dependent manner(P<0.05),with a maximum increase of 80.2%.All three ex-tracts significantly reduced the lipofuscin accumulation in C.elegans(P<0.05)in a dose-dependent manner with a maximum of 98.15%.High concentrations of three oyster extracts(800 μg/mL)significantly improved the movement ability of aging C.elegans,in-creased the survival rate of C.elegans damaged by paraquat(P<0.05)as well as the activity of GSH-Ps and SOD enzymes,and reduced MDA contents in vivo by 89.2%to 98.2%(P<0.05).The effects of three oyster extracts had the order of OP>EPO>WPO.In con-clusion,EPO,OP,and WPO showed different anti-aging effects.OP showed the best effect,which could provide a reference for further development of oyster foods for anti-aging.

关键词

牡蛎提取物/秀丽隐杆线虫/脂褐素/百草枯/抗衰老

Key words

oyster extract/Caenorhabditis elegans/lipofuscin/paraquat/anti-aging

引用本文复制引用

魏润霞,卢虹玉,秦小明,王丽瑶..牡蛎提取物对秀丽隐杆线虫的抗衰老作用研究[J].食品与发酵工业,2024,50(1):52-58,7.

基金项目

财政部和农业农村部国家现代农业产业技术体系资助项目(CARS-49) (CARS-49)

食品与发酵工业

OA北大核心CSTPCD

0253-990X

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