食品与发酵工业2024，Vol.50Issue(1)：98-104,7.DOI:10.13995/j.cnki.11-1802/ts.034345
酪蛋白胶束/聚乳酸静电纺丝复合纤维膜性质及其对黄芩苷的负载性能研究
Properties of casein micelle/poly(lactic acid)electrospinning composite fiber membrane and its loading capacity for baicalin
摘要
Abstract
Baicalin is a kind of flavonoids,which has anti-inflammatory,antibacterial,antiviral,and other pharmacological effects,but it has poor water solubility and low bioavailability.To improve the water solubility of baicalin,a casein micelle/poly(lactic acid)composite fiber membrane loaded with baicalin was prepared by electrospinning technology.The microstructure,hydrophobicity,solubili-ty,and in vitro release of baicalin were studied.Results showed that baicalin had little effect on the microstructure of the fibers.With the increase in the ratio of casein micelles,the fiber diameter decreased and the fiber-forming performance decreased.When the mass ratio of casein micelles to poly(lactic acid)reached 2∶1,the fiber diameter was the smallest and the fiber-forming ability was better.The results of infrared spectroscopy and X-ray diffraction showed that baicalin was encapsulated in the fibers.Moreover,casein micelles improved the swelling and degradation rate of poly(lactic acid)fiber membranes.With the increase of casein micelles,the hydrophilicity and degrada-tion rate of the membrane were enhanced,and the swelling rate and swelling time were reduced.In vitro release results showed that the casein micelle-poly(lactic acid)fiber membrane had a good controlled release effect on baicalin.The results can provide a reference for the load of baicalin.关键词
静电纺丝/黄芩苷/聚乳酸/酪蛋白胶束/复合纤维膜Key words
electrospinning/baicalin/polylactic acid/casein micelles/composite fiber membrane引用本文复制引用
甄晨波,杨敏,秦娟娟,郑杰,廖海周,魏彦明..酪蛋白胶束/聚乳酸静电纺丝复合纤维膜性质及其对黄芩苷的负载性能研究[J].食品与发酵工业,2024,50(1):98-104,7.基金项目
国家自然科学基金项目(32060812) （32060812）
国家现代农业产业技术体系项目(CARS-37) （CARS-37）
甘肃省高校产业支撑项目(2020C-14) （2020C-14）
甘肃省自然科学基金项目(22JR5RA861) （22JR5RA861）
