血清Sestrin2及sSema4D水平对冠状动脉慢血流现象的预测作用OACSTPCD
The predictive effect of serum Sestrin2 and sSema4D levels on slow coronary flow phenomenon
目的 分析血清应激诱导蛋白2(Sestrin2)及可溶性信号素 4d(sSema4D)水平与冠状动脉慢血流现象(CSFP)的关系及其预测CSFP的价值.方法 选取2020 年2 月—2022 年11 月赤峰学院附属医院心内科行冠状动脉造影检查未见明显病变但存在CSFP的患者 40 例为CSFP组,无冠状动脉狭窄和无CSFP的患者 40 例为非CSFP组.所有患者均行心肌梗死溶栓试验(TIMI),检测血清Sestrin2 及sSema4D水平,Pearson分析血清Sestrin2、sSema4D与TIMI的关系,多因素Logistic回归分析影响CSFP发生的危险因素,受试者工作特征曲线(ROC)分析血清Sestrin2及sSema4D预测CSFP的价值.结果 CSFP组血清Sestrin2、sSema4D水平均高于非CSFP组(t/P =21.058/<0.001、22.299/<0.001).CSFP组平均TIMI帧数高于非CSFP组(t/P =15.140/<0.001),TIMI血流分级≤2 级比例高于非CSFP组(Z/P =80.000/<0.001).CSFP组血清Sestrin2、sSema4D水平均与平均TIMI帧数呈正相关(r/P =0.442/<0.001、0.316/<0.001).男性、血管疾病、高Sestrin2、高sSema4D是CSFP的危险因素[OR(95%CI)=2.784(1.386～5.594)、2.038(1.086～3.823)、1.702(1.113～2.605)、1.531(1.070～2.192)];血清Sestrin2、sSema4D单独及二者联合预测CSFP的AUC分别为 0.707、0.753、0.873,二者联合优于各自单独预测价值(Z/P =3.047/<0.001、2.402/0.012).结论 CSFP患者血清Sestrin2、sSema4D水平均增高,且与TIMI分级增加和CSFP的发生有关.
Objective To analyze the relationship between serum stress-induced protein 2(Sestrin2)and soluble signaling hormone 4d(sSema4D)levels and coronary slow flow phenomenon(CSFP),and its predictive value for CSFP.Methods Forty patients who underwent coronary angiography at the Cardiology Department of Chifeng College Affiliated Hospital from February 2020 to November 2022 without obvious lesions but with CSFP were selected as the CSFP group.Forty patients without coronary artery stenosis and CSFP were selected as the non CSFP group.All patients underwent my-ocardial infarction thrombolysis test(TIMI)to detect serum levels of Sestrin2 and sSema4D.Pearson analyzed the relation-ship between serum Sestrin2,sSema4D,and TIMI.Multivariate logistic regression analysis was used to identify risk factors affecting the occurrence of CSFP.Receiver operating characteristic curve(ROC)analysis was used to assess the value of serum Sestrin2 and sSema4D in predicting CSFP.Results The serum levels of Sestrin2 and sSema4D in the CSFP group were higher than those in the non CSFP group(t/P=21.058/<0.001,22.299/<0.001).The average TIMI frame rate in the CS-FP group was higher than that in the non CSFP group(t/P=15.140/<0.001),and the proportion of TIMI blood flow grade≤2 was higher than that in the non CSFP group(Z/P=80.000/<0.001).The serum levels of Sestrin2 and sSema4D in the CSFP group were positively correlated with the average TIMI frame rate(r/P=0.442/<0.001,0.316/<0.001).Male,vascular disease,high Sestrin2,and high sSema4D are risk factors for CSFP[OR(95%CI)=2.784(1.386-5.594),2.038(1.086-3.823),1.702(1.113-2.605),1.531(1.070-2.192)].The AUC of serum Sestrin2 and sSema4D alone and in combination for predicting CSFP were 0.707,0.753,and 0.873,respectively.The combination of the two was superior to their respective individual pre-dictive values(Z/P=3.047/<0.001,2.402/0.012).Conclusion The serum levels of Sestrin2 and sSema4D in CSFP patients are both elevated,and are associated with an increase in TIMI grading and the occurrence of CSFP.
可钦;魏玮;杨蕙;杜晶;朱宏颖
024099 内蒙古自治区赤峰学院附属医院心内科
临床医学
冠状动脉慢血流现象应激诱导蛋白2可溶性信号素4d动脉粥样硬化氧化应激炎性反应
Coronary slow blood flow phenomenonStress-induced protein 2Soluble signaling hormone 4dAth-erosclerosisOxidative stressInflammatory response
《疑难病杂志》 2024 (001)
26-30 / 5
内蒙古自治区教育科学研究"十四五"规划立项课题(NGJGH2022356) Project Proposal for the 14th Five Year Plan of Education Science Research in Inner Mongolia Autonomous Region(NGJGH2022356)
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