疑难病杂志2024，Vol.23Issue(1)：37-40,45,5.DOI:10.3969/j.issn.1671-6450.2024.01.006
川崎病儿童血清可溶性生长刺激表达因子2、同型半胱氨酸表达水平与心血管受损的关系分析
Analysis of the relationship between serum sST2 and Hcy expression levels and cardiovascular damage in children with Kawasaki disease
摘要
Abstract
Objective To analyze the relationship between serum soluble growth stimulating factor 2(sST2)and homocysteine(Hcy)expression levels and cardiovascular damage in children with Kawasaki disease(KD).Methods Retro-spective analysis of clinical data of 104 KD patients from January 2020 to December 2022 at the Affiliated Women and Chil-dren's Hospital/Chengdu Women and Children's Center Hospital of University of Electronic Science and Technology of E-lectronic Science and Technology of China.Based on their cardiovascular damage,they were divided into a cardiovascular damaged group(damaged group)of 37 cases and a cardiovascular undamaged group(undamaged group)of 67 cases.Com-pare the differences in serum sST2 and Hcy levels between two groups of KD children,and use Spearman rank correlation analysis to evaluate the correlation between the severity of cardiovascular damage and serum sST2 and Hcy levels;Use re-ceiver operating curve(ROC curve)to evaluate the diagnostic value of serum sST2 and Hcy levels for cardiovascular dam-age in children with KD.Results The age of children in the damaged group was lower than that in the undamaged group(t/P=8.401/<0.001),and the proportion of patients who received the first intravenous injection of immunoglobulin(IVIG)for≥10 days was higher than that in the undamaged group(χ2/P=7.355/0.007).The serum levels of sST2 and Hcy in the damaged group were higher than those in the undamaged group(t/P=5.047/<0.001,5.503/<0.001),and increased with the severity of coronary artery disease in the damaged group(F/P=50.642/<0.001,55.362/<0.001);The Spearman rank correla-tion analysis results showed a significant positive correlation between serum sST2 and Hcy levels and the severity of cardi-ovascular damage in KD children(r/P=0.856/<0.001,0.870/<0.001);The combined prediction of serumsST2,Hcy,and two items for cardiovascular damage AUC was 0.895,0.814,and 0.911,respectively.The combined AUC of the two items was greater than its predicted AUC alone(Z=2.453,2.331,P=0.014,0.020).Conclusion Serum sST2 and Hcy play important roles in the diagnosis and treatment of cardiovascular damage in children with KD,and have high clinical application value.关键词
川崎病/心血管受损/可溶性生长刺激表达因子2/同型半胱氨酸Key words
Kawasaki disease/Cardiovascular damage/Soluble growth stimulating factor 2/Homocysteine分类
临床医学引用本文复制引用
杨蜜,刘成桂,廖志勇,沈伟,吴舒懋,舒慧英..川崎病儿童血清可溶性生长刺激表达因子2、同型半胱氨酸表达水平与心血管受损的关系分析[J].疑难病杂志,2024,23(1):37-40,45,5.基金项目
四川省卫生和计划生育委员会科研课题(16PJ075) Scientific Research Project of Sichuan Provincial Health and Family Planning Commission(16PJ075) （16PJ075）
