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外泌体在缺血性卒中诊断及治疗中的研究与应用OACSTPCD

Research and application of exosomes in the diagnosis and treatment of ischemic stroke

中文摘要英文摘要

缺血性卒中是最常见的脑卒中类型,可导致严重的神经功能障碍,但目前缺乏有效的诊断方法和治疗手段.外泌体是一种天然的囊泡,可以通过递送蛋白质、脂质、核酸发挥细胞间通讯的作用.缺血性卒中发生后,外泌体分泌量增加且内容物发生变化,因此可以作为潜在的生物标志物,用以辅助缺血性卒中的诊断和治疗.本文旨在综述外泌体在缺血性卒中中潜在的诊断价值,并探讨外泌体在卒中后的修复作用以及作为药物载体的应用前景,最后我们简要介绍了基于外泌体的临床研究现状.

Ischemic stroke(IS)is the most common type of stroke that can lead to severe neurological dysfunction while effective diagnostic and therapeutic methods are currently limited.Exosomes are natural vesicles that can play a key role in intercellular communication by delivering proteins,lipids,and nucleic acids.Notably,IS could cause changes in the level and content of exosome,which can serve as a potential biomarker to assist the diagnosis and treatment of IS.This article reviews the potential diagnostic value of exosomes,discusses their repair effects,and explores the potential applica-tion as drug carriers in IS.We also provide a concise summary of the current clinical research status based on exosomes.

尹文婧;曲瑒;任佳欣;马虹印;郭珍妮;杨弋

吉林大学第一医院神经专科医院卒中中心,吉林 长春 130021

临床医学

缺血性卒中外泌体诊断治疗药物输送

Ischemic strokeExosomeDiagnosisTreatmentDrug delivery

《中风与神经疾病杂志》 2024 (001)

3-6 / 4

吉林大学白求恩医学部(2022JBGS03);吉林省科技厅(YDZJ202302CXJD061、20220303002SF);吉林省重点实验室(YDZJ202302CXJD017)

10.19845/j.cnki.zfysjjbzz.2024.0001

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