中风与神经疾病杂志2024，Vol.41Issue(1)：35-40,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0007
远端缺血预处理对急性缺血性脑卒中炎症反应的作用及机制研究进展
Research advances in the role and mechanism of distal ischemic preconditioning on inflammatory response in acute ischemic stroke
摘要
Abstract
Acute ischemic stroke(AIS)is a common disease that threatens human life and health,and it has high disability and mortality rates.Ischemia-reperfusion injury(IRI)is a significant factor causing secondary injury of ischemic brain tissue during AIS treatment.In recent years,studies on the pathophysiological mechanism of ischemic stroke believe that IRI is the result of the combined action of multiple injury mechanisms,and the secretion of inflammatory factors and the infiltration of inflammatory cells play an extremely important role in the process of such injury.A large number of in-flammatory cell infiltration and inflammatory factor secretion can induce neuronal apoptosis or necrosis and lead to micro-vascular dysfunction,secondary cerebral hemorrhage or cerebral edema,thereby causing irreversible damage to the brain.The functional polymorphism of inflammatory genes may be an important factor affecting the incidence rate and outcome of ischemic stroke.Studies have shown that by regulating neuroinflammation and other mechanisms,remote ischemic precon-ditioning(RIPC)can effectively reduce IRI in cerebral tissue after ischemia in AIS patients,exert a cerebral protection ef-fect,and improve the prognosis of patients.This article reviews the role and mechanism of the regulation of inflammatory response by RIPC in AIS,so as to provide a reference for clinical prevention and treatment strategies for ischemic stroke and the research on related mechanisms.关键词
远端缺血预处理/急性缺血性脑卒中/缺血再灌注损伤/炎症反应Key words
Remote ischemic preconditioning/Acute ischemic stroke/Ischemia-reperfusion injury/Inflam-matory response分类
医药卫生引用本文复制引用
朱芸燕,张传武,陈靖,曾名望,杨超,张文福,梁伟东..远端缺血预处理对急性缺血性脑卒中炎症反应的作用及机制研究进展[J].中风与神经疾病杂志,2024,41(1):35-40,6.基金项目
江西省自然科学基金面上项目(20224BAB206039) （20224BAB206039）
