中国免疫学杂志2024，Vol.40Issue(1)：21-30,10.DOI:10.3969/j.issn.1000-484X.2024.01.003
NK细胞代谢途径及其功能
Metabolism and function of NK cells
摘要
Abstract
NK cells are important components of innate immune system and play a key role in immune responses.Activation of NK cells mainly depends on dynamic balance between activatory and inhibitory receptors expressed on surface.However,in many chronic diseases,balance between these receptors of NK cells is disorder,resulting in reduced cytolysis activity and cytokine produc-tion,which is in a state of immune inactivation.In recent years,many studies have shown that intracellular metabolism is crucial for immune cells such as NK cells,and changes of metabolism will regulate functions of immune cells by affecting cell development,pro-liferation and activity.In view of powerful anti-tumor and anti-viral effects of NK cells and their important clinical application value,it is important to study their metabolic characteristics and mechanisms.This review mainly introduces metabolic patterns of NK cell,related regulatory pathways,regulatory effects of metabolism on NK cell development,memory and functions,and metabolism-based NK cell therapy,also expounds important role of metabolism on NK cell biosynthesis,stability and effector function in vivo,as well as metabolism-related factors involved in NK cell inactivation in different chronic diseases,providing a solid research basis for clinical application of NK cell therapy.关键词
NK细胞/免疫失活/代谢/细胞治疗Key words
NK cells/Immune inactivation/Metabolism/Cell therapy分类
医药卫生引用本文复制引用
于雅婷,张建..NK细胞代谢途径及其功能[J].中国免疫学杂志,2024,40(1):21-30,10.基金项目
国家重点研发计划(2021YFC2300603). （2021YFC2300603）
