中国食品学报2023，Vol.23Issue(12)：37-50,14.DOI:10.16429/j.1009-7848.2023.12.005
平阴玫瑰花色苷的鉴定及对LPS/AGEs/4-HNE诱导炎症的抑制
Identification of Pingyin Rose Anthocyanins and Inhibition of LPS/AGEs/4-HNE Induced Inflammation
摘要
Abstract
Pingyin rose was approved as a new resource food in 2010,which is a unique rose resource food in Shan-dong province of China.Anthocyanins were extracted and preliminarily identified from Pingyin rose.RAW264.7 macrophages were induced by lipopolysaccharide(LPS),advanced glycation end products(AGEs)and 4-hydroxynonenal(4-HNE)to construct inflammatory model.The effects of anthocyanins on the production of reactive oxygen species(ROS)and nitric oxide(NO)and the expression of some inflammatory factors in RAW264.7 cells were studied.Results showed that rose anthocyanins mainly contained two aglycones,namely cyanidin and peonidin.A total of six anthocyanins were identified,including three cyanidin-dihexoses,two peonidin dihexoses and peonidin-rutinose-hexose.Anthocyanins could significantly inhibit the production of ROS and NO and the expression of IL-1β,IL-6,TNF-α,iNOS in RAW264.7 cells,showing a good inhibitory effect on inflammation.关键词
平阴玫瑰/花色苷/鉴定/炎症/抑制/RAW264.7细胞Key words
Pingyin rose/anthocyanin/identification/inflammatory/inhibition/RAW264.7 cells引用本文复制引用
吕雯雯,吴华,肖俊松,曹雁平,雷胜明..平阴玫瑰花色苷的鉴定及对LPS/AGEs/4-HNE诱导炎症的抑制[J].中国食品学报,2023,23(12):37-50,14.基金项目
北京市自然科学基金项目(6212002) （6212002）
北京市教委一般项目(KM202010011010) （KM202010011010）
