中国食品学报2023，Vol.23Issue(12)：97-104,8.DOI:10.16429/j.1009-7848.2023.12.011
小麦肽对非甾体抗炎药致肠损伤的修复作用
Protective Effect of Wheat Peptides on Non-steroidal Anti-inflammatory Drug-injured Intestinal Mucosa
摘要
Abstract
Objective:To investigate the effect of wheat peptides on intestinal damage from non-steroidal anti-inflammato-ry drugs(NSAIDs).Methods:The 4-week-old male KM mice were randomly divided into 6 groups according to body weight,namely blank group(saline gavage),diclofenac sodium group(diclofenac sodium gavage),glutamine group(di-clofenac sodium+glutamine),wheat peptide low,medium and high dose groups(diclofenac sodium+different doses of wheat peptide),10 mice in each group,and treated continuously for 21 days.Mice were fasted for 12 h after the final gavage and weighed.Mice were subjected to blood sampling for oxidative stress levels and adrenaline E2(PGE2)assays.Mouse intestine tissue was collected for histopathological testing and western blot was used to detect the expression of in-testinal tissue tight junction proteins.Results:Compared with the diclofenac sodium group,mice in the wheat peptides and glutamine groups had higher body weights,lower levels of oxidative stress and restored PGE2 expression to normal levels.The mucosal barrier damage in mouse intestinal tissues was improved and the expression of tight junction protein was increased.Conclusion:Wheat peptides have protective effects against diclofenac sodium-induced intestinal disorders.It is promising to provide an effective method to protect against NSAIDs intestinal barrier function impairment.关键词
非甾体抗炎药/小麦肽/肠黏膜屏障/紧密连接蛋白Key words
non-steroidal anti-inflammatory drugs/wheat peptides/intestinal mucosal barrier/tight junction protein引用本文复制引用
冯志远,刘丹,张卓然,徐锦珍,李明亮,刘文君..小麦肽对非甾体抗炎药致肠损伤的修复作用[J].中国食品学报,2023,23(12):97-104,8.基金项目
宁夏回族自治区重点研发计划项目(2021BEG02027) （2021BEG02027）
