中国食物与营养2023，Vol.29Issue(11)：58-62,36,6.
叶酸代谢相关基因的多态性对学龄前儿童神经心理发育的影响
Impact of Gene Polymorphisms Associated with Folate Metabolism on Neuropsychological Development of Preschool Children
摘要
Abstract
[Objective]To investigate the impact of single nucleotide polymorphisms(SNPs)in key enzymes of the folate metabolic pathway,including methylenetetrahydrofolate reductase(MTHFR),methionine synthase reductase(MTRR)and methionine synthase(MTR),on neuropsychological development in Han preschool children.[Method]A total of 318 Han Chinese pre-school children from Guiding and Song counties were recruited to genotype the four loci MTHFR(A1298C/C677T),MTRR(A66G)and MTR(A2756G)using KASP SNP typing technology to investigate the impact of these four SNPs on DQ and MI.[Result]The study revealed that the disparities in DQ and MI among genotype groups at the MTHFR C677T locus were statistically significantly different(P＜0.05).The disparity in DQ among the diverse genotype groups at the MTHFR A1298C locus exhibited statistical significance(P＜0.01).Conversely,there were no statistically significant variances in DQ and MI between genotype groups at MTRR A66G and MTR A2756G loci(P＞0.05).Defining MTHFR 1298AA/CC and MTHFR 677CT/TT as genotypes carrying risk,a statistically significant difference in DQ was observed between groups with varying numbers of risk genotypes(P＜0.01).[Conclusion]The MTHFR 1298CC pure mutant type is protective against neuropsychological development,and the T mutation in the MTHFR C677T locus increases the risk of neuropsychological disorders in children.The MTRR A66G and MTR A2756G loci are not associated with neuropsychological development in preschool children.关键词
叶酸/基因多态性/神经心理发育Key words
folic acid/genetic polymorphism/neuropsychological development引用本文复制引用
彭锣兰,韩超,卓勤,赵金鹏,石丽丽,李岩,宫照龙..叶酸代谢相关基因的多态性对学龄前儿童神经心理发育的影响[J].中国食物与营养,2023,29(11):58-62,36,6.基金项目
早期儿童营养包干预长期营养健康作用评估项目(项目编号:131031107000200001). （项目编号:131031107000200001）
