摘要
Abstract
[Objective]To explore the effect of folic acid combined with vitamin B12adjuvant therapy on clinical efficacy and vascular endothelial cell function in patients with H-type hypertension.[Method]A randomized controlled trial method was used to include 70 patients with H-type hypertension who attended the Affiliated Hospital of Jiangnan University from April 2020 to April 2022 as study subjects.A simple random sampling method was used to randomly divide the patients into 35 cases each in the observation group and the control group.The control group received amlodipine benzoate tablets,and the observation group added folic acid and vitamin B12 on top of the next,and both groups underwent the intervention for 12 weeks.Changes in blood pressure,serum homocysteine(Hey),endothelin-1(ET-1),vascular endothelial growth factor(VEGF),interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)levels were observed in both groups before and after the intervention.[Result]Folic acid combined with vitamin B12adjuvant therapy in patients with H-type hypertension showed better antihypertensive effect compared with antihypertensive drugs alone(91.43％vs 71.43％,P＜0.05),could better reduce serum Hey levels[(8.93±2.19)vs(15.87±3.74)µmol/L],and could better control serum IL-6,hs-CRP,ET-1 and VEGF levels,all with statistically significant differences(P＜0.05).[Conclusion]In the actual clinical treatment of patients with H-type hypertension,folic acid and vitamin B12 can be added as adjuvant therapy.关键词
H型高血压/叶酸/维生素B12/同型半胱氨酸/血管内皮功能Key words
H-type hypertension/folic acid/vitamin B12/homocysteine/vascular endothelial function
