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肠道寄生虫与肠道微生物相互作用研究进展OACSTPCD

Research Progress on the Interaction Between Intestinal Parasites and Intestinal Microorganisms

中文摘要英文摘要

在脊椎动物的肠道内,存在着数量庞大、结构多样、动态变化的微生物群,它们对肠道的生理、代谢、免疫等具有重要的作用.在自然条件下,这些微生物和真核生物(如蠕虫、原生动物、真菌等)共同存在于脊椎动物肠道内.寄生虫与微生物群均可显著改变机体肠道生理与免疫环境,为它们之间的相互作用创造了机会.肠道微生物与寄生虫之间的相互作用会极大地影响感染的结果,进而对宿主的健康产生重要影响.如寄生虫感染会影响宿主与微生物的相互作用关系,从而促使或保护宿主免受细菌的侵害.另一方面,菌群又会影响寄生虫的定植、繁殖和毒性,使其沿着与宿主寄生性-互惠共生性的生存模式发展.这些相互作用的机理与结果是微生物学与寄生虫学之间交叉研究的前沿课题.笔者对近年来有关肠道寄生虫与肠道微生物间相互作用的最新研究成果进行了总结,并对其可能未考虑到的因素提出了自己的观点,旨在为肠道寄生虫病防控及肠道菌群研究提供参考.

In the intestines of vertebrates,there are a large number of structurally diverse and dynamically changing microbiota,which play important roles in the physiology,metabolism,and immunity of the intestine.Under natural conditions,these microorganisms and eukaryotes(such as worms,protozoa,fungi,etc)co-exist in the vertebrate intestine.Both parasites and microbiota can significantly alter the intestinal physiology and immune environment,creating opportunities for interaction between them.The interaction between gut microbes and parasites can greatly affect the outcome of infection,which in turn has important implications for host health.For example,parasitic infections affect host-microbial interactions to promote or protect the host from bacteria.On the other hand,the flora affects the colonization,reproduction and toxicity of the parasite,causing it to develop along the survival pattern of parasitic-reciprocal symbiosis with the host.The mechanism and results of these interactions are frontier topics in the cross-research between microbiology and parasitology.This article summarizes the latest research results on the interaction between intestinal parasites and intestinal microbiota in recent years,and puts forward its own views on factors that may not be taken into account,aiming to provide reference for the prevention and control of intestinal parasitic diseases and the study of intestinal microbiota.

李思瑶;侯斌;玛丽雅其其格;哈斯苏荣

内蒙古农业大学兽医学院,农业农村部动物疾病临床诊疗技术重点实验室,国家级动物医学实验教学中心,呼和浩特 010018乌审旗动物疫病预防控制中心,鄂尔多斯 017300

畜牧业

肠道寄生虫肠道微生物相互作用

intestinal parasitesintestinal microorganismsinteraction

《中国畜牧兽医》 2024 (001)

330-337 / 8

鄂尔多斯重大专项(2022EEDSKJZDZX026);乌审旗动物疫病预防控制中心横向课题

10.16431/j.cnki.1671-7236.2024.01.033

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