噬菌体裂解酶在畜禽生产中的应用研究进展OACSTPCD

The long-term and large-scale irregular use of antibiotics in livestock and poultry production has led to the increasingly serious problem of bacterial resistance,which has brought great difficulties to the prevention and treatment of bacterial diseases in livestock and poultry,and even threatened public health security.Phage lysin is a peptidoglycan hydrolase encoded by phage,which can kill bacteria efficiently and specifically and has anti-biofilm activity.It has become a new antibacterial agent and has been included in the treatment strategy of bacterial infection,especially drug-resistant bacterial infection.In livestock and poultry production,phage lysin has been successfully used in the prevention and treatment of bacterial diseases caused by Gram-positive bacteria such as Staphylococcus aureus and Streptococcus,while the application of phage lysin on Gram-negative bacteria such as Escherichia coli and Salmonella is still in the in vitro research stage.In this paper,the structural characteristics,mechanism of action and application of phage lysin in livestock and poultry production were reviewed,and the application status and prospect of phage lysin in livestock and poultry production were explored,in order to provide reference for further application of phage lysin in prevention and control and treatment of bacterial diseases.