中国畜牧兽医2024，Vol.51Issue(1)：357-364,8.DOI:10.16431/j.cnki.1671-7236.2024.01.036
噬菌体裂解酶在畜禽生产中的应用研究进展
Research Progress on the Application of Phage Lysin in Livestock and Poultry Production
摘要
Abstract
The long-term and large-scale irregular use of antibiotics in livestock and poultry production has led to the increasingly serious problem of bacterial resistance,which has brought great difficulties to the prevention and treatment of bacterial diseases in livestock and poultry,and even threatened public health security.Phage lysin is a peptidoglycan hydrolase encoded by phage,which can kill bacteria efficiently and specifically and has anti-biofilm activity.It has become a new antibacterial agent and has been included in the treatment strategy of bacterial infection,especially drug-resistant bacterial infection.In livestock and poultry production,phage lysin has been successfully used in the prevention and treatment of bacterial diseases caused by Gram-positive bacteria such as Staphylococcus aureus and Streptococcus,while the application of phage lysin on Gram-negative bacteria such as Escherichia coli and Salmonella is still in the in vitro research stage.In this paper,the structural characteristics,mechanism of action and application of phage lysin in livestock and poultry production were reviewed,and the application status and prospect of phage lysin in livestock and poultry production were explored,in order to provide reference for further application of phage lysin in prevention and control and treatment of bacterial diseases.关键词
噬菌体/裂解酶/畜禽生产/细菌性疾病Key words
phage/lysin/livestock and poultry production/bacterial diseases分类
农业科技引用本文复制引用
刘成,常钦源,范国庆,王志伟,王丽静,丁宁宁,路建彪,司振书,李玉保..噬菌体裂解酶在畜禽生产中的应用研究进展[J].中国畜牧兽医,2024,51(1):357-364,8.基金项目
山东省重点研发计划(重大科技创新工程)项目(2022CXGC010606) （重大科技创新工程）
山东省自然科学基金项目(ZR2022MC107) （ZR2022MC107）
聊城大学科研基金(318012105) （318012105）
大学生创新创业训练计划项目(CXCY2022243、202310447197) （CXCY2022243、202310447197）
