中国药理学与毒理学杂志2024，Vol.38Issue(1)：46-55,10.DOI:10.3867/j.issn.1000-3002.2024.01.006
环状RNA在大脑功能调控及药物成瘾中的作用研究进展
Research progress in roles of circular RNA in brain function regulation and drug addiction
摘要
Abstract
Circular RNA(circRNA)is an emerging class of endogenous non-coding RNA,which is widely expressed in the brain and plays an important role in a variety of biological processes.Research has shown that circRNA plays a key role in physiological and pathological processes of the brain,such as neurodevelopment,synaptic plasticity and neurodegenerative diseases through a variety of mecha-nisms such as adsorption of microRNA,binding to proteins and translation of peptides.In the field of drug addiction,the expression of circRNA is significantly changed in animal models and brains of addicts,and the regulation involves neural adaptation in brain regions that form the reward circuit such as the nucleus accumbens and prefrontal cortex.Additionally,addiction-related circRNAs are closely associated with neurotransmitter systems,signaling pathways,and neuroinflammatory responses,and they influ-ence the formation and maintenance of drug addiction by modulating gene expression networks related to drug addiction.Here,the biogenesis and regulatory mechanism of circRNA as well as its important role in brain function and drug addiction are reviewed in order to provide a new perspective for explora-tions of the pathological mechanism of drug addiction.关键词
环状RNA/中枢神经系统疾病/药物成瘾Key words
circular RNA/central nervous system disease/drug addiction分类
医药卫生引用本文复制引用
杨茜茜,高菲菲,杨潇宇,高靖麒,张玉向,阎春霞..环状RNA在大脑功能调控及药物成瘾中的作用研究进展[J].中国药理学与毒理学杂志,2024,38(1):46-55,10.基金项目
国家自然科学基金(81971792) National Natural Science Foundation of China(81971792) （81971792）
