中国药理学与毒理学杂志2024，Vol.38Issue(1)：70-78,9.DOI:10.3867/j.issn.1000-3002.2024.01.008
电离辐射生物标志物研究与应用进展
Advances in research and application of ionizing radiation biomarkers
欧红玲 1艾文超 2王岩 1马盈盈 1时磊 1张巧云 1宋秀军 1王欣茹1
作者信息
- 1. 火箭军特色医学中心检验科,北京 100088
- 2. 火箭军广州特勤疗养中心体检科,广东广州 510515
- 折叠
摘要
Abstract
Exposure to ionizing radiation intervenes in genomic stability and gene expression,resulting in the disruption of normal metabolic processes in cells and organs by causing complex biolog-ical responses.Altered genomic variations,gene expression and metabolite concentrations in blood or tissue samples reflect systemic radiation damage.With the application of new techniques and exten-sive study on the mechanisms for ionizing radiation damage,related indicators such as chromosomal variation,gene expression,lipid and metabolism are being recognized and promise to be the markers for early diagnosis and prognosis of radiation exposure.Therefore,this article reviews recent progress in and potential applications of biomarkers related to ionizing radiation injury.关键词
电离辐射/分子诊断/标志物Key words
ionizing radiation/molecular diagnostics/biomarkers分类
医药卫生引用本文复制引用
欧红玲,艾文超,王岩,马盈盈,时磊,张巧云,宋秀军,王欣茹..电离辐射生物标志物研究与应用进展[J].中国药理学与毒理学杂志,2024,38(1):70-78,9.
