一株中华稻蝗内生真菌Fusarium lateritium ZMT01的代谢产物OACSTPCD

The metabolites of an endophytic fungus Fusarium lateritium ZMT01 from Oxya chinensis Thunbergwere investigated.The fungus was cultured in rice medium,the monomeric compounds were isolated and purified by the chromatographic technique,and the structures of compounds were identi-fied by analysis of spectroscopy.Ten compounds were isolated and identified as fusopoltide A(1),fusopoltide B(2),fusopoltide D(3),solaniol(4),javanicin(5),(1S,4S,10S)-3,4-dihydro-6,9-dihydroxy-8-methoxy-10-(2-oxopropyl)-1,4-methano-2-benzoxepin-5(1H)-one(6),2,2′-methy-lenebis(4-methyl-6-tert-butylphenol)(7),2-hydroxymethyl-5-isopropoxy-4-methoxynaphthalen(8),β-sitosterol(9)and walterolactone A(10).Among them,compounds 8 and 10 were firstly obtained from the genus Fusarium,and all of them except compound 9 were isolated from Fusarium lateritium for the first time.The antibacterial activities of these compounds were tested in vitro using the two-fold dilution method.Compounds 4 and 5 showed a high inhibitory activity against Escherichia coli with se-rotype O6 with MIC of 6.25 µg/mL,and compound 4 showed a moderate inhibitory activity against Fu-sarium oxysporum with MIC of 200 µg/mL.