中国现代医生2024，Vol.62Issue(2)：15-20,6.DOI:10.3969/j.issn.1673-9701.2024.02.004
外周血炎症指标对初诊多发性骨髓瘤患者预后的预测价值
Predictive value of peripheral blood inflammatory indicators in patients with new-diagnosed multiple myeloma
摘要
Abstract
Objective To explore the predictive value of peripheral blood inflammatory indicators such as neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR)and platelet-to-lymphocyte ratio(PLR)on the prognosis of patients with primary diagnosis of multiple myeloma(MM).Methods Using a retrospective method,77 patients with first diagnosis of MM admitted to the Department of Hematology of Baise People's Hospital and 77 healthy medical checkups with peripheral blood NLR,MLR and PLR were collected and compared the differences.Then the patients with primary diagnosis of MM were categorized into high NLR group,low NLR group,high MLR group,low MLR group,high PLR group,low PLR group using the mean value as the critical value,and the prognosis of the patients in each group as well as the relationship with overall survival time(OS)were compared.Results The NLR,MLR,and PLR of patients with initial diagnosis of MM were significantly higher than those of healthy controls,and the differences were statistically significant(all P<0.05).Serum β2-microglobulin(β2-MG)levels were higher in patients with high NLR and high MLR than in the low NLR and low MLR groups,and the difference was statistically significant(P<0.05).Patients in the high NLR,high MLR and high PLR groups had less OS and poorer prognosis than those in the low NLR,low MLR and low PLR groups,and the differences were statistically significant(all P<0.05).Univariate Cox regression analysis showed that international staging system(ISS)stage,creatinine(Cr),β2-MG,albumin(ALB),NLR,MLR and PLR were associated with overall survival(P<0.05);multivariate Cox proportional risk regression analysis showed that NLR,MLR,and PLR were not independent risk factors affecting the prognosis of patients with primary diagnosis of MM,and the difference was not statistically significant(P>0.05).According to the number of inflammatory indexes(high NLR,high MLR,high PLR)that affected the prognosis,the patients were divided into 0 or 1 risk factor group,2 risk factor groups and 3 risk factor groups,and the comparison of OS between the three groups was statistically significant(P=0.001).The greater the number of concomitant risk factors for prognosis,the shorter the OS.Conclusion Elevated inflammatory indicators(NLR,MLR,PLR)in patients with primary diagnosis of MM were associated with less OS and poorer prognosis of the patients,and they may be used as indicators to assess the condition and prognosis of patients with primary diagnosis of MM.关键词
多发性骨髓瘤/炎症指标/中性粒细胞与淋巴细胞比值/单核细胞与淋巴细胞比值/血小板与淋巴细胞比值/预后Key words
Multiple myeloma/Inflammatory indicators/Neutrophil-to-lymphocyte ratio/Monocytes to lymphocytes ratio/Platelet-to-lymphocyte ratio/Prognosis分类
医药卫生引用本文复制引用
黄宵莓,黄柏明,黄训俊,吴菁,李若林..外周血炎症指标对初诊多发性骨髓瘤患者预后的预测价值[J].中国现代医生,2024,62(2):15-20,6.基金项目
广西自然科学基金项目(2020GXNSFAA297052) （2020GXNSFAA297052）
广西医药卫生适宜技术推广项目(S2018076) （S2018076）
