犬静脉滴注丙氨酰谷氨酰胺注射液的安全性研究OACSTPCD

To evaluate the safety of injecting alanyl-glutamine(Ala-Gln)in target animals,24 healthy adult Beagles were enrolled and randomly divided into four groups:the one-fold dose group(0.4 g/kg),the three-fold dose group(1.2 g/kg),the five-fold dose group(2.0 g/kg),and the blank control group(0.9%saline injection,with the same volume as the five-fold dose group),with six dogs in each group.Ala-Gln injection was diluted and mixed with 0.9%saline injection at an equal volume of the five-fold dose and intravenously infused at a rate of 20-30 drops/min once daily for 14 days.During the experiment,clinical manifestations,blood physiological and biochemical in-dicators,and urine routine indicators were observed in the dogs,and the dogs in both the blank control and five-fold dose groups were select-ed for gross dissection and histopathological examination.The results showed that the clinical manifestations of the dogs in each dose group were normal and all the physiological and biochemical indicators of blood and urine routine were within the normal range.No pathological changes were found in the gross dissection and histopathological examination of the dogs in the five-fold dose group.Therefore,this study suggested that Ala-Gln injection at 1,3,5 times the dose of intravenous drip for 14 days,once a day,was safe for target animal dogs.