苏贝止咳颗粒急性气管支气管炎药效学实验研究OA北大核心CSTPCD

AIM:To observe the effect of Su Bei Zhi Ke granules(SBZKG)on acute tracheobronchitis(Syndrome of Wind-cold Attacking Lung).METH-ODS:Mouse ear swelling experiment and mouse abdominal capillary permeability experiment was used to observe its anti-inflammatory effect.Cough test in mice induced by ammonia water,and phlegm test in rats were used to observe the expec-torant and antitussive effects of phenol red test in mice.We used the mortality rate experiment of in-fected mice to observe its antibacterial and antivi-ral effects.RESULTS:Compared with the contral group,the large and medium dose groups of SBZKG both reduced mouse auricle swelling(P＜0.05)and increased swelling inhibition rate,reducing mouse abdominal capillary permeability(P＜0.05,P＜0.01).SBZKG can increase the phenol red sputum output in the respiratory tract of mice(P＜0.01),prolong the cough incubation period of mice,reduce the number of coughs in mice(P＜0.05,P＜0.01),and in-crease the sputum output in rats(P＜0.05,P＜0.01).SBZKG can reduce the mortality rate of mice infect-ed with bacteria and viruses.CONCLUSION:SBZKG has certain anti-inflammatory,antitussive,expecto-rant,antibacterial and antiviral effects,and has cer-tain therapeutic effects on acute tracheobronchitis.