中国兽医杂志2024，Vol.60Issue(1)：9-14,6.
2例犬口腔肉瘤的病理学分析
Pathological Analysis of Two Cases of Canine Oral Sarcoma
摘要
Abstract
Oral sarcomas are common oral tumors in dogs,particularly in geriatric dogs.In this study,two cases of oral masses in dogs were subjected to histopathological analysis using hematoxylin and eosin(H.E.)staining and immunohistochemistry detection.H.E.staining revealed proliferating spindle cells and local melanin granules in the tumor tissues of both dogs.Secondary hemorrhage and necrotic cystic changes were observed.Under high magnification,cells exhibited pleomorphism,atypia,prominent nucleoli,and frequent mitosis,leading to a preliminary diagnosis of malignant melanoma or soft tissue sarcoma.Immunohistochemical results showed negative expression of broad-spectrum cytokeratin(CKp)and positive expression of vimentin in both cases,epithelial membrane antigen(EMA)in case 1 and human cytokeratin antigen cluster(Cam5.2)in case 2 were negatively expressed,indicating an interstitial origin of the tumor.Specific antibodies such as Melan-A,S-100,and human melanoma black-45(HMB45)were all negative,reducing the possibility of melanoma and nerve sheath sarcoma.In case 1,α-smooth muscle actin(SMA)and Desmin were partially positive in some areas,suggesting partial myogenic differentiation.Case 2 showed no expression of myogenic markers.In conclusion,both cases of oral masses in dogs were diagnosed as high-grade soft tissue sarcomas.关键词
犬/口腔肿瘤/组织病理/免疫组织化学/肉瘤Key words
dog/oral tumor/histopathology/immunohistochemistry/sarcoma分类
农业科技引用本文复制引用
苏真,王华南,惠天朝,韦方华,徐亚嵩,张舒六,许世军,吴旧生,师福山,林琳..2例犬口腔肉瘤的病理学分析[J].中国兽医杂志,2024,60(1):9-14,6.基金项目
深圳市瑞鹏基金会与新瑞鹏宠物医疗集团科研基金项目(2021-KYY-683000-0002) （2021-KYY-683000-0002）
温州市宠物工程技术研究中心开放课题(WP05) （WP05）
