医药导报2024，Vol.43Issue(3)：365-373,9.DOI:10.3870/j.issn.1004-0781.2024.03.006
老年重症肿瘤的诊疗策略
Diagnosis and Treatment Strategies for Severe Tumors in the Elderly
摘要
Abstract
Patients with severe tumors do not refer to the patients with end-stage tumors,but rather to the patients with a performance status(PS)score between 2 and 4 in certain stages due to various reasons,such as acute or chronic comorbidities,tumor itself,or treatment-related adverse events.To these patients,there is a high probability of achieving survival benefit and/or improvement in PS scores after synergistic management of available life-support technologies and anti-tumor therapies based on dynamic and precise testing.Elderly patients with tumors frequently present with one or more chronic illnesses and have poor toler-ance and compliance to treatment.Moreover,their treatment regimens often lack high-quality clinical evidence,making them more susceptible to developing severe tumors.The management of severe tumors in the elderly is based on three basic diagnosis and treatment technologies:dynamic and precise detection,powerful life support technologies,and skillful application of current anti-tumor treatments.In specific clinical practice,the following 7 flexible and individualized treatment strategies should be adopted for different tumor types:1.concurrent management of cancer and comorbidities,2.upgrading and downgrading of anti-tumor drugs based on PS score,3.dynamic accurate detection,4.skillful combinations for increasing efficacy and reducing toxicity,5.complete overview,paying equal attention to systemic therapy and local therapy,6.safety first in medication for the elderly,7.multi-discipli-nary participation,individualized and comprehensive treatment.This article introduced the concept of severe tumors in the elderly and the associated management strategies,to increase awareness and provide feasible guidance for clinical practice.关键词
重症肿瘤/老年患者/诊疗策略Key words
Severe tumors/Elderly patients/Diagnosis and treatment strategy分类
医药卫生引用本文复制引用
王李强,邓海怡,刘明,林心情,谢晓鸿,谢展鸿,秦茵茵,欧阳铭,周承志..老年重症肿瘤的诊疗策略[J].医药导报,2024,43(3):365-373,9.基金项目
希思科临床肿瘤学研究基金资助项目(Y-HS202102-0118) （Y-HS202102-0118）
中国初级卫生保健基金会资助项目(BH001496). （BH001496）
