中国食品添加剂2024，Vol.35Issue(2)：1-8,8.DOI:10.19804/j.issn1006-2513.2024.2.001
人参茎叶中丙二酰基人参皂苷对APAP诱导的小鼠肝损伤的保护及作用机制
Protective effects and mechanisms of malonyl-ginsenosides in ginseng stems and leaves on APAP-induced acute liver injury in mice
摘要
Abstract
An acetaminophen(APAP)-induced mouse liver injury model was established to study the protective effect of malonyl ginsenoside extract(MGR)from ginseng stems and leaves on acute liver injury in mice and to explore the MGR's potential function mechanism.Mice were randomly divided into blank group,APAP model group,and MGR high-dose and low-dose groups,and liver injury models were established and administered.The serum levels of alanine transferase(ALT),aspartate transferase(AST),interleukin-1β(IL-1β),tumor necrosis factor α(TNF-α)and malondialdehyde(MDA)and glutathione(GSH)in mice liver tissues were measured,and the pathological changes were observed by sectioning.Compared with the APAP group,the elevated serum levels of ALT,AST,IL-1β,and TNF-α were decreased,the elevated MDA was suppressed and the GSH was decreased in MGR groups.Protein blot analysis showed that MGR increased the expression of p-PI3K,p-AKT and Bcl-2 and decreased the expression of Bax in mice.MGR had protective effect on APAP-induced acute liver injury in mice,and the mechanism of its protective effect may be related to inflammation,oxidative stress,and cell apoptosis.关键词
丙二酰基人参皂苷提取物/对乙酰氨基酚/肝损伤/人参Key words
malonyl ginsenoside extract/acetaminophen/liver injury/ginseng分类
轻工纺织引用本文复制引用
王佳美,王东升,李嘉星,李泽文,陆雅倩,刘志..人参茎叶中丙二酰基人参皂苷对APAP诱导的小鼠肝损伤的保护及作用机制[J].中国食品添加剂,2024,35(2):1-8,8.基金项目
国家自然科学基金(NO.31770378). （NO.31770378）
