脑干带状高信号的软脑膜转移临床特征分析OACSTPCD

Objective:To analysis the clinical features of leptomeningeal metastasis with banded high signal in the brain-stem.Methods:This study has collected data of patients with band-like high signal in brainstem manifested by MRI from the first Affiliated Hospital of Hainan Medical University,searched the databases of CNKI,Wanfang,VIP,PubMed,Web of Science,and other databases which reported the MRI manifestation of"brainstem band-like high signal",and collected the patients'past medical history,symptoms,signs,genetic findings,cerebrospinal fluid manifestation,treatment,and prognosis.Results:A total of 28 patients were included,of whom 26 had a history of lung adenocarcinoma and two were found to have occupational changes in the lungs.MRI showed a band-like high signal in the ventral part of the brainstem on T2-FLAIR,symmetrical on both sides,which could extend to the cerebellar peduncles,with high signals on diffusion-weighted imaging(DWI),low signals on apparent diffusion coefficient(ADC),and long T1 signals on T1-weighted imaging,long T2 signals on T2 weighted imaging,and no long T2 signals on enhancement scan.T1-weighted imaging was a long T1 signal,T2-weighted imaging was a long T2 signal,and no enhancement was seen on enhanced scanning.Conclusion:It is important to recognize leptomeningeal metastasis of lung cancer,and the non-enhancing band of high signal in the brainstem on T2-FLAIR and DWI is likely to be the characteristic manifestation of leptomeningeal metastasis of non-small cell lung cancer.