海南医学院学报2024，Vol.30Issue(4)：273-278,6.DOI:10.13210/j.cnki.jhmu.20231129.001
脑干带状高信号的软脑膜转移临床特征分析
Analysis of clinical characteristics of leptomeningeal metastasis with band-like high signal in the brainstem
摘要
Abstract
Objective:To analysis the clinical features of leptomeningeal metastasis with banded high signal in the brain-stem.Methods:This study has collected data of patients with band-like high signal in brainstem manifested by MRI from the first Affiliated Hospital of Hainan Medical University,searched the databases of CNKI,Wanfang,VIP,PubMed,Web of Science,and other databases which reported the MRI manifestation of"brainstem band-like high signal",and collected the patients'past medical history,symptoms,signs,genetic findings,cerebrospinal fluid manifestation,treatment,and prognosis.Results:A total of 28 patients were included,of whom 26 had a history of lung adenocarcinoma and two were found to have occupational changes in the lungs.MRI showed a band-like high signal in the ventral part of the brainstem on T2-FLAIR,symmetrical on both sides,which could extend to the cerebellar peduncles,with high signals on diffusion-weighted imaging(DWI),low signals on apparent diffusion coefficient(ADC),and long T1 signals on T1-weighted imaging,long T2 signals on T2 weighted imaging,and no long T2 signals on enhancement scan.T1-weighted imaging was a long T1 signal,T2-weighted imaging was a long T2 signal,and no enhancement was seen on enhanced scanning.Conclusion:It is important to recognize leptomeningeal metastasis of lung cancer,and the non-enhancing band of high signal in the brainstem on T2-FLAIR and DWI is likely to be the characteristic manifestation of leptomeningeal metastasis of non-small cell lung cancer.关键词
软脑膜转移/带状高信号/肺腺癌/磁共振成像/脑脊液/血脑屏障Key words
Leptomeningeal metastasis/Band-like high signal/Lung adenocarcinoma/Magnetic resonance imaging/Ce-rebrospinal fluid/Blood-brain barrier分类
医药卫生引用本文复制引用
林慧霞,刘婷,杨逸昊,栗菲,梁斌基,李丽娟,李治群,李其富..脑干带状高信号的软脑膜转移临床特征分析[J].海南医学院学报,2024,30(4):273-278,6.基金项目
This study was supported by Hainan Clinical Medical Center Construction Project(2021) （2021）
Excellent Talent Team of Hainan Province(QRCBT202121) （QRCBT202121）
Key R&D Program of Hainan Province(ZDYF2022SHFZ109)海南省临床医学中心建设项目(2021) （ZDYF2022SHFZ109）
海南省优秀人才团队(QRCBT202121) （QRCBT202121）
海南省重点研发计划(ZDYF2022SHFZ109) （ZDYF2022SHFZ109）
