海藻玉壶汤治疗桥本甲状腺炎临床研究OACSTPCD

Objective:To explore the effect of Haizao Yuhu Decoction(海藻玉壶汤)in treatment of Hashimoto thyroiditis and its effect on thyroid autoimmune antibodies and Th1/Th2 related cytokines.Methods:A total of 94 patients with Hashimoto thyroiditis were divided into the observation group and the control group by using random number table method,with 47 cases in each group.The control group was treated with selenium yeast tablets and levothyroxine sodium tablets,and the observation group was treated with Haizao Yuhu Decoction on the basis of the treatment of the control group.The course of treatment in both groups was three months.Chinese medicine symptom score and total effective rate,thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPO-Ab),free triiodothyronine(FT3),free tetraiodothyronine(FT4),thyroid stimulating hormone(TSH),interleukin-10(IL-10),interleukin-12(IL-12),interferon-γ(INF-γ)content were compared between the two groups,and the adverse reactions were observed.Results:After treatment,scores of goiter,foreign body sensation in pharynx,chest tightness and hypochopathy,fatigue,and serum levels of TGAb,TPO-Ab,TSH,IL-12 and IFN-γ in both groups were lower than those before treatment,and the indexes of the observation group were lower than those of the control group(all P＜0.05).Serum FT3,FT4 and IL-10 levels in two groups were higher than those before treatment,and the indexes of the observation group were lower than those of the control group(all P＜0.05).The total effective rate was 95.74％in the observation group and 82.98％in the control group(P＜0.05).There were no adverse events in both groups.Conclusions:Haizao Yuhu Decoction combined with conventional western medicine has a good effect in the treatment of Hashimoto thyroiditis.It can reduce the level of thyroid autoantibodies and restore thyroid function.The mechanism may be involved in improving thyroid function by down-regulating Th1 cytokine and up-regulating Th2 cytokine.