山东中医杂志2024，Vol.43Issue(1)：41-46,92,7.DOI:10.16295/j.cnki.0257-358x.2024.01.009
海藻玉壶汤治疗桥本甲状腺炎临床研究
Clinical Study of Haizao Yuhu Decoction(海藻玉壶汤)in Treatment of Hashimoto Thyroiditis
摘要
Abstract
Objective:To explore the effect of Haizao Yuhu Decoction(海藻玉壶汤)in treatment of Hashimoto thyroiditis and its effect on thyroid autoimmune antibodies and Th1/Th2 related cytokines.Methods:A total of 94 patients with Hashimoto thyroiditis were divided into the observation group and the control group by using random number table method,with 47 cases in each group.The control group was treated with selenium yeast tablets and levothyroxine sodium tablets,and the observation group was treated with Haizao Yuhu Decoction on the basis of the treatment of the control group.The course of treatment in both groups was three months.Chinese medicine symptom score and total effective rate,thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPO-Ab),free triiodothyronine(FT3),free tetraiodothyronine(FT4),thyroid stimulating hormone(TSH),interleukin-10(IL-10),interleukin-12(IL-12),interferon-γ(INF-γ)content were compared between the two groups,and the adverse reactions were observed.Results:After treatment,scores of goiter,foreign body sensation in pharynx,chest tightness and hypochopathy,fatigue,and serum levels of TGAb,TPO-Ab,TSH,IL-12 and IFN-γ in both groups were lower than those before treatment,and the indexes of the observation group were lower than those of the control group(all P＜0.05).Serum FT3,FT4 and IL-10 levels in two groups were higher than those before treatment,and the indexes of the observation group were lower than those of the control group(all P＜0.05).The total effective rate was 95.74％in the observation group and 82.98％in the control group(P＜0.05).There were no adverse events in both groups.Conclusions:Haizao Yuhu Decoction combined with conventional western medicine has a good effect in the treatment of Hashimoto thyroiditis.It can reduce the level of thyroid autoantibodies and restore thyroid function.The mechanism may be involved in improving thyroid function by down-regulating Th1 cytokine and up-regulating Th2 cytokine.关键词
桥本甲状腺炎/海藻玉壶汤/甲状腺自身免疫性抗体/甲状腺激素/Th1/Th2细胞因子Key words
Hashimoto thyroiditis/Haizao Yuhu Decoction/thyroid autoimmune antibodies/thyroid hormone/Th1/Th2 cytokines分类
医药卫生引用本文复制引用
田林涛,王新梅,郭笑丹,雷烨,魏文静..海藻玉壶汤治疗桥本甲状腺炎临床研究[J].山东中医杂志,2024,43(1):41-46,92,7.基金项目
陕西省中医药管理局科研课题(编号:LCMS051) （编号:LCMS051）
陕西中医药大学第二附属医院学科创新团队项目(编号:2019-QN02) （编号:2019-QN02）
