食品工业科技2024，Vol.45Issue(6)：337-342,6.DOI:10.13386/j.issn1002-0306.2023050132
银杏内酯B对肥胖小鼠的改善作用研究
Ameliorating Effect of Ginkgolide B on Obese Mice
摘要
Abstract
This study aims to explore the effect of ginkgolide B(GB)on obese mice.An obese C57BL/6J mice model was induced by high-fat diet firstly,and then the obese mice were divided into 4 groups according to body weight randomly:Positive model group(PG),GB low dose group(GBL),GB medium dose group(GBM)and GB high dose group(GBH).After 8-week intervention,the obesity-related indexes(weight change,visceral fat coefficient and serum indexes)of mice in each group were measured.Results showed that the weight gain of mice in GBM and GBH were significantly decreased than in PG(P<0.05),and the visceral fat coefficient of mice in GBH group was also reduced significantly(P<0.05)after GB treatment.Meanwhile,the serum indexes(TG,TC,LDL-C and HDL-C)of mice in GBM and GBH were obviously improved,especially in GBH.Besides,histopathologic findings showed that liver fat deposition was apparently reduced in GBM and GBH.Furthermore,qRT-PCR results showed that the mRNA expression level of PPARγ in liver of mice in GBM and GBH was significantly decreased(P<0.05)in comparison with PG,while the mRNA expression level of UCP-2 was significantly increased(P<0.05).In summary,this study demonstrated that GB of medium and high doses improved obesity in mice,and this ameliorating effect might be related to PPARγ-UCP-2 signaling pathway.关键词
银杏内酯B/肥胖/小鼠/银杏/改善作用Key words
ginkgolide B/obesity/mice/gingko/ameliorating effect分类
轻工纺织引用本文复制引用
尹忞强,罗来庆,汤海莲,陈金女,李琴,黄露怡,焦宇知..银杏内酯B对肥胖小鼠的改善作用研究[J].食品工业科技,2024,45(6):337-342,6.基金项目
江苏高校自然科学研究项目(21KJA350001). （21KJA350001）
