中国动物检疫2024，Vol.41Issue(2)：47-57,11.DOI:10.3969/j.issn.1005-944X.2024.02.010
动物疫病活载体疫苗研究进展
Research Progress on Live Vector Vaccines for Animal Diseases
摘要
Abstract
The live vector vaccine,as one of the most promising genetic engineering vaccines currently and mainly used in the field of animal disease prevention and control,is a carrier system expressing exotic antigens and therapeutic factors by taking bacteria or viruses as vectors,characterized by the advantages of high safety,low risk of virulence reversion,low cost,inducing immune organisms to produce high-level humoral,cellular or mucosal immunity,etc.Virus vectors include DNA viruses(such as adenovirus,adeno-associated virus and smallpox virus)and RNA viruses(such as Newcastle disease virus and influenza virus);and bacterial vectors include attenuated pathogenic bacteria and non-pathogenic bacteria,mainly including Lactobacillus,Salmonella,Escherichia coli,etc.Vector-host balanced lethal system and microbial surface display system are the antigen presentation strategies commonly used by live vector vaccines,which,in combination with the development of multiple vaccine vectors,maximize the value of live vector vaccines.The optimal and most suitable live vector vaccines should be selected as appropriate,depending on their respective advantages and disadvantages in preventing diseases.In the paper,research progress on viral and bacterial live vector vaccines in the field of animal disease prevention and control was reviewed,with a view to providing a reference for relevant efforts in the future.关键词
活载体疫苗/病毒载体/细菌载体/疫苗开发/抗原呈递Key words
live vector vaccine/viral vector/bacterial vector/vaccine development/antigen presentation分类
农业科技引用本文复制引用
周凯钰太,潘俊慧,王素春,禹兰平,杨文静,梁晚枫,孙福亮,王楷宬..动物疫病活载体疫苗研究进展[J].中国动物检疫,2024,41(2):47-57,11.基金项目
中国动物卫生与流行病学中心创新基金项目 （）
