北京社区55～75岁高、低痴呆风险人群身体素质及其认知功能特点OA北大核心CSTPCD

Objective To analyze the risk factors of dementia among healthy elderly individuals in the middle of their lives. Methods A total of 175 participants aged 55 to 75 from two communities in Beijing were included from July,2021 to April,2023.Cardiovascular Risk Factors,Aging,and Incidence of Dementia(CAIDE)related risk factors and other demographic data were collected.According to the CAIDE assessment,participants with scores≥9 were as high-risk group,and those with scores<9 were as low-risk group.They were evaluated with Stroop Color Word Test(SCWT),two elements 1-back task paradigm and the revised Trail Making Test(TMT);measured the grip strength,30 s forearm flexion tests and five sit-to-stand tests;the average step speed and step length of a 10-me-ter walk were recorded. Results The average total score of CAIDE was 9.86 in the high-risk group,and was 4.95 in the low-risk group.There was no difference in age between two groups(P = 0.188).There were differences in the proportion of participants of male,less than seven years'education,systolic blood pressure>140 mmHg,cholesterol>6.5 mmol/L,body mass index>30 kg/m2,and lack of physical activity between two groups(χ2>3.116,P<0.05).The grip strength(t =-4.174),walking speed(t =-2.414),SCWT accuracy(Z =-2.684)were all worse in the high-risk group than in the low-risk group(P<0.05).Logistic regression analysis showed that walking speed(OR = 25.483),grip strength(OR = 1.133)and SCWT accuracy(OR = 37.430)were independent influencing factors of dementia(P<0.05). Conclusion Weaker grip strength,slower gait speed and worse inhibitory control might be independent influencing fac-tors of dementia.