经鼻高流量氧疗与无创机械通气治疗慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭的效果OA

Objective:To evaluate the effect of high flow nasal cannula(HFNC)and non-invasive ventilation(NIV)in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with type Ⅱ respiratory failure.Method:A total of 97 patients with AECOPD complicated with type Ⅱ respiratory failure admitted to Department of Emergency Medicine,Hechi Third People's Hospital from May 2021 to May 2023 were selected and divided into HFNC group(n=49)and NIV group(n=48)according to random number table method.HFNC group was given HFNC treatment,NIV group was given NIV treatment.The hospital stay,breathing support time,dyspnea improvement time,arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2),pH value,general comfort questionnaire(GCQ)score,treatment discontinuation rate,fatality rate and incidence rate of complications were compared between the two groups.Result:There were no significant differences in hospital stay,breathing support time and dyspnea improvement time between the two groups(P>0.05).After treatment,there were no significant differences in pH value,SaO2 and PaO2 between the two groups(P>0.05),but PaCO2 in HFNC group was higher than that in NIV group(P<0.05).There was no significant difference in 28 d fatality rate between the two groups(P>0.05).The GCQ score in HFNC group was higher than that in NIV group,and the rate of treatment discontinuation and complication were lower than those in NIV group(P<0.05).Conclusion:HFNC and NIV have similar effects in the treatment of AECOPD complicated with type Ⅱ respiratory failure,but HFNC has higher comfort,lower risk of complications and treatment discontinuation.