临床输血与检验2024，Vol.26Issue(1)：49-54,6.DOI:10.3969/j.issn.1671-2587.2024.01.008
双重滤过血浆单采清除肾移植术前群体反应性抗体临床疗效及安全性观察
Efficacy and Safety of Double Filtration Plasmapheresis to Remove High PRA Antibody before Kidney Transplantation
刁玉洁 1朱帮强 1闻慧琴 1王海婧 1胡艳 1程越 1卞茂红1
作者信息
- 1. 安徽医科大学第一附属医院输血科 230022
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy and safety of double filtration plasmapheresis(DFPP)in clearing panel reactive antibody(PRA)before renal transplantation.Methods The changes of PRA in 11 patients with PRA positive before kidney transplantation and after DFPP treatment in our hospital from January 2021 to June 2023 were retrospectively analyzed.Parameters such as routine blood,liver function and anticoagulation were monitored before and after treatment.Results PRA in 11 patients with end-stage renal failure decreased significantly after DFPP treatment,from positive to negative or weakly positive.Except for one patient who gave up kidney transplantation because of poor general conditions,the other patients underwent kidney transplantation successfully.Sixty-two DFPP treatments were performed.There were no significant changes in RBC,HGB,PLT,ALB,TBIL,PT,APTT,K,Na,Cl,HCO3-compared with patients before and after DFPP treatment(P＞0.05).Conclusion DFPP can effectively reduce the high PRA index before renal transplantation and reduce the risk of acute rejection after renal transplantation,and the treatment process is safe.关键词
肾移植/双重滤过血浆单采/群体反应性抗体Key words
Kidney transplant/Double filtration plasmapheresis/Panel reactive antibody分类
医药卫生引用本文复制引用
刁玉洁,朱帮强,闻慧琴,王海婧,胡艳,程越,卞茂红..双重滤过血浆单采清除肾移植术前群体反应性抗体临床疗效及安全性观察[J].临床输血与检验,2024,26(1):49-54,6.
