吉兰-巴雷综合征患者抗GM1抗体与抗甲状腺抗体的相关性研究OA北大核心CSTPCD

Objective:We aimed to explore the relationship between thyroid autoantibodies and anti-GM 1 antibody in Guillain-Barre syndrome(GBS)patients.Methods:We selected 60 GBS patients who were admitted to Nanjing Drum Tower Hospital from July 2018 to February 2023 and tested for both anti-thyroid antibodies and Antiganglioside antibody(AGA)levels.According to anti-thyroid antibodies,the patients were divided into normal group and abnormal group.The clinical characteristics,thyroid function and the proportion of AGA in the two groups were compared.Results:Compared with the normal group,GBS patients in the abnormal group had significantly increased anti-GM1 antibody(Ab)(P＜0.05)and anti-GM2 Ab(P＜0.05),and were accompanied by more severe clinical symptoms(P＜0.05).Multivariate logistic regression analysis showed that the presence of abnormal anti-thyroid antibodies[OR=5.184,95％CI:1.377-19.518,P=0.015]and increased free thyroxine(FT4)levels[OR=1.266,95％CI:1.009-1.588,P=0.030]were independent risk factors for increased anti-GM1 antibody positive rate in GBS patients.Receiver operation characteristic(ROC)curve analysis found that the optimal threshold for thyroperoxidase antibody(TPO-Ab)to predict anti-GM 1 Ab positive was 47.9 U/mL,with a sensitivity of 66.7％and a specificity of 77.8％.The optimal threshold for thyroglobulin antibody(Tg-Ab)to predict anti-GM 1 Ab positive was 20.0 U/mL,with a sensitivity of 73.3％and a specificity of 73.3％.Conclusion:Our results suggest an association between thyroid autoantibodies and anti-GM1 antibody in GBS patients,potentially explaining the poorer prognosis of GBS patients with thyroid dysfunction.