中国临床药理学与治疗学2024，Vol.29Issue(3)：303-309,7.DOI:10.12092/j.issn.1009-2501.2024.03.009
0.01％阿托品滴眼液对不同程度近视儿童黄斑微循环的影响
Effects of low concentration atropine on macular microcirculation in children with different degrees of myopia
摘要
Abstract
AIM:To investigate the effects of 0.01％atropine eye drops on macular blood flow density and retinal thickness in children with differ-ent degrees of myopia.METHODS:This was a pro-spective case-control study.Sixty-four patients(112 eyes)diagnosed with myopia for the first time with 0.01％atropine eye drops before and 6 months af-ter medication were investigated with the uncor-rected distance visual acuity(UCVA),axial length(AL),spherical equivalent(SE),macular ganglion cell-inner plexiform layer thicknes(mGCIPL)using slit lamp examination and optical coherence to-mography(OCT),vascular density in the macular ar-ea and the area of the avascular in the fovea using optical coherence tomography angiography(OC-TA).Changes in various indicators before and after medication were compared.RESULTS:Compared with before medication,the AL of the three groups of myopia patients increased significantly(P＜0.01),the difference in low to moderate myopia group was significantly smaller than that in high myopia group.Compared with before medication,SE in-creased in all three groups of myopia patients,yet there was no statistically significant difference in the low-grade myopia group(P＞0.05).The differ-ence was statistically significant between the mod-erate myopia group and the high myopia group(P＜0.01).Compared with before medication,there was no change in intraocular pressure(IOP)among the three groups of myopic patients(P＞0.05).After 6 months of medication,the central circle macular vessel density(cCVD)increased in the low myopia group and moderate myopia group(P＜0.01),there was no statistically significant difference in the high myopia group(P＞0.05).Before and after medica-tion,there was no significant difference in outer circle macular vessel density(oCVD),inner circle macular vessel density(iCVD),and whole circle macular vessel density(wCVD)among the three myopia groups(P＞0.05).The increase in mGCIPL was statistically significant in the low myopia group(P＜0.01),but there was no statistically significant difference in the moderate myopia and high myo-pia groups(P＞0.05).There was no significant differ-ence in foveal avascular zone(FAZ)among the three myopia groups before and after medication(P＞0.05).There was no correlation between CVD,AL,and SE in the three myopia groups(P＞0.01).There was a low correlation between CVD and mG-CIPL in the low myopia group(r=0.442,P＜0.05),there was no correlation between CVD and mGCIPL in the moderate myopia and high myopia groups(P＞0.01).CONCLUSION:0.01％atropine can signifi-cantly reduce the rate of axial and refractive growth in children with low to moderate myopia,increase the density of central macular vessels,and increase the thickness of mGClPL in children with low to moderate myopia.关键词
0.01％阿托品滴眼液/神经节细胞-内丛状层/黄斑血流密度/近视Key words
low concentration atropine/ganglion cell-inner plexiform layer/macular blood flow den-sity/myopia分类
医药卫生引用本文复制引用
葛薇,盛文燕,许琦彬,诸力伟,李秋实..0.01％阿托品滴眼液对不同程度近视儿童黄斑微循环的影响[J].中国临床药理学与治疗学,2024,29(3):303-309,7.基金项目
杭州市医药卫生科技项目(A20210130 （）
A20230193) （）
浙江省中医药科技计划项目(2022ZB261) （2022ZB261）
杭州市生物医药和健康产业发展扶持科技专项(2023WJC174) （2023WJC174）
浙江省医药卫生科技计划项目(2024KY1359) （2024KY1359）
杭州市医学重点学科(眼科学0020200468) （眼科学0020200468）
