昆明医科大学学报2024，Vol.45Issue(2)：14-22,9.DOI:10.12259/j.issn.2095-610X.S20240203
KRAS基因3'UTR多态性与云南汉族人群宫颈癌及宫颈上皮内瘤变的相关性
Correlation of KRAS Gene 3'UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province
摘要
Abstract
Objective To investigate the correlation between rs712 and rs7973450 located at the 3'UTR region of the KRAS gene and the risk of cervical cancer(CC)and cervical intraepithelial neoplasia(CIN)in Chinese Han population in Yunnan province.Methods A total of 2405 individuals(461 subjects with CIN,961 subjects with CC and 983 healthy controls)were enrolled.The SNPs were genotyped used TaqMan assay and the correlation of these SNPs with CIN and CC was analyzed.Results The A allele of rs7973450 might be a protective factor for the occurrence of CIN(P = 0.004,OR= 0.651,95%CI 0.487～0.871)and CC(P = 7.00×10-4,OR= 0.667,95%CI 0.529～0.844).There was no significant difference in allelic and genotypic distribution of rs712 among CIN,CC and Control groups(P>0.017).The haplotype assay showed thatrs712A-rs7973450G was associated with increased risk of CIN(P = 4.00×10-4;OR= 1.714,95%CI 1.269～2.314)and CC(P = 3.84×10-5,OR= 1.667,95%CI 1.305～2.131).While haplotype rs712A-rs7973450A was associated with a lower risk of CC(P = 0.012,OR= 0.790,95%CI 0.658～0.950).Conclusion The A allele of rs7973450 in 3'UTR of KRAS gene might be the protective factor for the occurrence of CIN and CC in a Chinese Han population in Yunnan province.关键词
KRAS基因/单核苷酸多态性/宫颈癌/宫颈上皮内瘤变/云南汉族人群相关性Key words
KRAS/Single nucleotide polymorphism/Cervical cancer/Cervical intraepithelial neoplasia/Han population in Yunnan分类
医药卫生引用本文复制引用
郭妮,张承,洪超,刘伟鹏,姚宇峰,严志凌..KRAS基因3'UTR多态性与云南汉族人群宫颈癌及宫颈上皮内瘤变的相关性[J].昆明医科大学学报,2024,45(2):14-22,9.基金项目
国家自然科学基金资助项目(82103190) （82103190）
云南省基础研究计划项目(202201AY070001-139 （）
202201AU070163) （）
