基于数据挖掘现代中医外治病理性瘢痕的用药规律研究OACSTPCD

Objective To explore and analyze the prescriptions rules of pathological scar treated with external traditional Chinese medicine(TCM)in three major Chinese journal databases.Methods The literatures related to the external therapeutic scar of TCM prescriptions were collected from China National knowledge infrastructure(CNKI)Database,Wanfang and VIP databases.Excel software was used to construct the information and composition of the prescriptions,SPSS statistic and IBM SPSS Modeler 18 were used for statistical analysis.Results A total of 92 prescriptions for the external treatment of pathological scar were obtained,including 206 TCM flavors.The Chinese medicines with frequency≥10 and higher frequency were Salvia miltiorrhiza,Schisandra chinensis,Angelica dahurica,Icicle,Centipede,Angelica sinensis,Sophora flavescens,Safflower,Liquorice,Rhioxma Curcumae aeruginosae,Rhizoma ligustici chuanxiong and rhubarb,respectively.The flavor of the medicine is mainly bitter and pungent,the property is more cold and warm,and the main meridian is the liver,spleen and lung,and the effect is mainly heat clearing,blood circulation and blood stasis medicine.18 core drug pairs based on association rules such as:Centipede-Chinese gallnut;Salvia miltiorrhiza radix-Chinese gallnut;Chinese Gallnut-Borneol.According to the cluster analysis,there were four new prescriptions:Chinese Gallnut,Honey,Stephania tetrandra,Centipede and Salvia miltiorrhiza;Rhioxma Curcumae aeruginosae,kelp,Sophora flavescens,Clematis chinensis Osbeck;Angelica dahurica,Angelica sinensis,Radix arnebiae,Sanguis draxonis,Liquorice;Rheum officinale,Phellondendron amurense,Alum.Conclusion The results of data mining show that the external treatment of pathological scar of TCM is mostly used to clear heat and detoxify,promote blood circulation and remove blood stasis,so as to achieve the effect of soft and firm the keloids and removing the hypertrophic scar.