摘要
Abstract
Objective:To analyze the potential therapeutic targets and mechanism of Lizhong decoction in the treatment of allergic rhinitis based on network pharmacology,so as to provide direction and reference for clinical application and later research.Methods:Mechanism of Lizhong decoction in the treatment of allergic rhinitis was analyzed by using multi-data platforms,the active components and drug targets of Lizhong decoction were retrieved and screened in Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).Targets were standardized with Uniprot database.GeneCards,Online Mendelian Inheritance in Man(OMIM),Comparative Toxicogenomics Database(CTD),Therapeutic Target Database(TTD)databases were retrieved to search and obtain the related genes of allergic rhinitis.Intersection therapeutic targets were obtained by Venn diagram and imported into STRING database for analysis,and the protein-protein interaction(PPI)network was established.The core key targets were enriched by gene ontology(GO)function and Kyoto Encyclopedia of genes and genomes(KEGG)signaling pathway analysis.Results:The key chemical components of Lizhong decoction in the treatment of allergic rhinitis were quercetin,kaempferol,β-sitosterol,α-amyrin,naringenin.The core targets were tumor necrosis factor(TNF),serine/threonine protein kinase(AKT1),interleukin-6(IL-6),tumor suppressor gene P53(TP53)and interleukin-1β(IL-1β).Lizhong decoction signaling pathway in the treatment of allergic rhinitis mainly included IL-17 signaling pathway,advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway,lipid and atherosclerosis signaling pathway,TNF signaling pathway,Toll-like receptor signaling pathway,and Th17 cell differentiation pathway.Conclusion:This study preliminarily reveals the multi-component,multi-target and multi-channel mechanism of Lizhong decoction in the treatment of allergic rhinitis,and provided reference for the clinical application and experimental research of Lizhong decoction.关键词
过敏性鼻炎/理中汤/网络药理学/信号通路/分子机制Key words
allergic rhinitis/Lizhong decoction/network pharmacology/signaling pathway/molecular mechanism分类
医药卫生
