儿科药学杂志2024，Vol.30Issue(3)：23-27,5.DOI:10.13407/j.cnki.jpp.1672-108X.2024.03.006
盐酸左西替利嗪冻干口崩片的制备
Preparation of Leoxitirizine Hydrochloride Lyophilized Orally Disintegrating Tablets
邱旖 1孙腾跃 2蔡程科 1王洪飞 2吴雪纯 1孙常胜 1吴婧楠 1蒋巧萍 1宇泉霖 1宋嘉佳 1武阳洋 2张欣悦2
作者信息
- 1. 北京中医药大学中药学院,北京 102488
- 2. 北京量子高科制药科技有限公司,北京 102200
- 折叠
摘要
Abstract
Objective:To design the preparation technology of leoxitirizine hydrochloride lyophilized orally disintegrating tablets by freeze drying method and evaluate its quality.Methods:Levocetirizine hydrochloride lyophilized orally disintegrating tablets were prepared by freeze-drying method.The appearance,disintegration time and taste of the finished products were investigated by single factor,and the prescription was optimized by orthogonal experiment.Results:The optimal prescription of leoxitirizine hydrochloride orally disintegrating tablets were levocetirizine-β-cyclodextrin inclusion complex 11.25 mg per tablet,glycine 10 mg per tablet,pullulan 8 mg per tablet,sucralose 0.5 mg per tablet,white peach flavor 1.5 μL per tablet.Leoxitirizine hydrochloride lyophilized orally disintegrating tablets with beautiful appearance,quick disintegration in the mouth and good taste were prepared.Conclusion:The preparation process of leoxitirizine hydrochloride lyophilized orally disintegrating tablets is stable and reliable,which can be used for large-scale production.关键词
盐酸左西替利嗪/冷冻干燥/口腔崩解片/制备工艺Key words
leoxitirizine hydrochloride/freeze drying/orally disintegrating tablets/preparation technology分类
医药卫生引用本文复制引用
邱旖,孙腾跃,蔡程科,王洪飞,吴雪纯,孙常胜,吴婧楠,蒋巧萍,宇泉霖,宋嘉佳,武阳洋,张欣悦..盐酸左西替利嗪冻干口崩片的制备[J].儿科药学杂志,2024,30(3):23-27,5.
